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Eplerenone

Eplerenone Side Effects

Kaitlyn Ellis, PharmD CandidateDaisy Chau, PharmD
Reviewed by Kaitlyn Ellis, PharmD Candidate, Daisy Chau, PharmD, Connie Zheng, PharmD
Last reviewed on June 5, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Digestive system problems (20%)
  • Nervous system problems (15%)
  • Urinary tract problems (14%)
  • Shortness of breath (7%)
  • Skin problems (7%)
  • Mental health problems (7%)
  • Cough (5%)

Less Common Side Effects

  • Headache
  • Dizziness
  • Chest pain or heart attack
  • Enlargement of male breasts (gynecomastia)
  • Abnormal vaginal bleeding

Eplerenone serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • High potassium (hyperkalemia): irregular heart beat, nausea, muscle pain and weakness, numbness and tingling

Source: DailyMed

The following Eplerenone side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Excess of cholesterol in the blood

excess of triglycerides in the blood

Incidence not known

Abdominal or stomach pain

arm, back, or jaw pain

chest pain or discomfort

chest tightness or heaviness

confusion

difficulty with breathing

dizziness

fast or irregular heartbeat

headache

irregular heartbeat

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

nausea

nervousness

numbness or tingling in the hands, feet, or lips

pain or discomfort in the arms, jaw, back, or neck

rash

shortness of breath

sweating

vomiting

weakness or heaviness of the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Abnormal vaginal bleeding

breast pain

chills

cloudy urine

cough

diarrhea

fever

general feeling of discomfort or illness

joint pain

loss of appetite

muscle aches and pains

swelling of the breasts or breast soreness in both females and males

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Kaitlyn Ellis, PharmD candidate, has 5 years of experience in various areas of the medical field, including women's health, community pharmacy, and hospital pharmacy experience.
Daisy Chau, PharmD
Reviewed by:
Daisy Chau, PharmD
Daisy Chau, PharmD, is the drug information pharmacist manager at GoodRx. She is licensed in California and has more than 6 years of experience working as a pharmacist in drug information.

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