Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Spironolactone vs. Eplerenone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Spironolactone (Aldactone)
    Eplerenone (Inspra)
  • Spironolactone (Aldactone)
    Eplerenone (Inspra)

  • Summary of Spironolactone vs. Eplerenone

    Summary for Potassium sparing diuretic
    Prescription only

    Spironolactone (Aldactone) is a type of potassium-sparing diuretic (water pill). It's used to treat heart failure, high blood pressure, and swelling from kidney or liver problems in adults. Because it blocks aldosterone (a hormone that affects sodium and potassium levels), spironolactone (Aldactone) can also treat conditions where there's too much aldosterone. Spironolactone (Aldactone) is taken by mouth, generally once or a few times a day, depending on your condition. Some common side effects of this medication include breast tenderness (males and females) and loss of libido (in males).

    Summary for Aldosterone receptor antagonist
    Prescription only

    Eplerenone (Inspra) is a medication that’s used to treat high blood pressure and improve survival among people with heart failure after a heart attack. It comes as an oral tablet that can be taken alone or in combination with other medications. Look out for side effects including dizziness, nausea, cough, and shortness of breath. Eplerenone (Inspra) is available as a generic tablet and also under the brand name Inspra.

  • Indications of Spironolactone vs. Eplerenone

    Indications for
    •Heart failure
    •High blood pressure
    •Swelling due to liver damage (cirrhosis)
    •Swelling due to nephrotic syndrome (a rare kidney condition) - tablets only
    •Primary aldosteronism (a hormone imbalance) - tablets only
    Indications for
    •Heart failure after a heart attack
    •High blood pressure

  • Pros and Cons of Spironolactone vs. Eplerenone

    Pros and Const for Potassium sparing diuretic
    Pros
    •Taken by mouth
    •Oral suspension available for adults who've difficulty swallowing tablets
    •Lower-cost generics available
    Cons
    •Can make you urinate more often
    •Need to get blood tests regularly to check your electrolytes and kidney health
    •Can cause breast growth and lower sex drive in males
    Pros and Const for Aldosterone receptor antagonist
    Pros
    •Improves survival for people with heart failure after a heart attack
    •Fewer side effects than spironolactone
    •Typically once daily dosing
    Cons
    •Have to get regular blood tests while taking the medication to check for high potassium levels
    •Not safe to use with severe kidney problems
    •Isn’t a first-choice medication for high blood pressure or heart failure

  • Common Side Effects of Spironolactone vs. Eplerenone

    Common Side Effects for
    •Dizziness
    •Headache
    •Sleepiness
    •Nausea
    •Vomiting
    •Diarrhea
    •Stomach cramps
    •Enlargement of male breasts
    •Breast pain
    •Lower sex drive
    •Sexual dysfunction
    •Irregular or lack of menstrual periods
    •Leg cramps
    •Higher potassium levels
    •Lower sodium levels
    Common Side Effects for
    •Digestive system problems (20%)
    •Nervous system problems (15%)
    •Urinary tract problems (14%)
    •Shortness of breath (7%)
    •Skin problems (7%)
    •Mental health problems (7%)
    •Cough (5%)

  • Warnings of Spironolactone vs. Eplerenone

    Common Side Effects for
    •High blood potassium levels
    •Low blood pressure and kidney problems
    •Abnormal electrolyte levels
    •Breast pain or swelling
    Common Side Effects for
    •High potassium (hyperkalemia)

  • Prices with our coupons for Spironolactone vs. Eplerenone

    Learn more about Spironolactone
    Learn more about Eplerenone

Compare other Heart Failure and Hypertension drugs

Enalapril vs SpironolactoneHydrochlorothiazide vs SpironolactoneLasix vs SpironolactoneLisinopril vs SpironolactonePropecia vs SpironolactoneSpironolactone vs DigoxinSpironolactone vs EdecrinSpironolactone vs TretinoinCatapres vs HydrochlorothiazideEnalapril vs AltaceEnalapril vs AtacandEnalapril vs AvaproEnalapril vs BenicarEnalapril vs ChlorthalidoneEnalapril vs DiovanEnalapril vs EdecrinEnalapril vs FelodipineEnalapril vs HydrochlorothiazideEnalapril vs LasixEnalapril vs LopressorEnalapril vs LosartanEnalapril vs MavikEnalapril vs MonoprilEnalapril vs NifedipineEnalapril vs NimodipineEnalapril vs SularEnalapril vs Toprol XlFelodipine vs HydrochlorothiazideHydrochlorothiazide vs CoregHydrochlorothiazide vs Digoxin
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.