Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Spironolactone (Aldactone) and ethacrynic acid (Edecrin) are both diuretics, but they work differently and are used for different reasons. Spironolactone is a potassium-sparing diuretic that helps treat heart failure, high blood pressure, and swelling from kidney or liver problems. It blocks aldosterone, a hormone that affects sodium and potassium levels, and is available in both tablet and oral suspension forms. Ethacrynic acid, on the other hand, is a loop diuretic mainly used to reduce swelling in people who can't take sulfa drugs. It works by removing certain electrolytes and extra fluid from your body. Unlike spironolactone, ethacrynic acid can cause temporary hearing loss and is more expensive. Spironolactone can cause side effects like breast tenderness and lower sex drive, while ethacrynic acid can lead to dizziness, loss of appetite, and high uric acid levels. Both medications require regular blood tests to monitor electrolytes and kidney function.
Ethacrynic acid, also known by its brand name Edecrin, is a strong diuretic (water pill) for treating edema (swelling). It's a loop diuretic that can be used for people who have a sulfa allergy and can't take other diuretics in the same drug class. Ethacrynic acid (Edecrin) is a tablet that's taken by mouth, but the specific dosage depends on the medical condition that's causing the edema. Common side effects include tiredness, headache, and loss of appetite.
•Short-term management of ascites (buildup of fluid in the stomach) due to cancer, edema from an unknown cause, or lymphedema (swelling caused by fluid buildup in the lymphatic system)
Pros and Cons of Spironolactone vs. Edecrin
Pros and Const for Potassium sparing diuretic
Pros
•Taken by mouth
•Oral suspension available for adults who've difficulty swallowing tablets