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Dapsone vs. Tretinoin

Dapsone is a tablet that's used for treating a skin condition called dermatitis herpetiformis and leprosy in children and adults. It belongs to the drug class known as sulfones. This medication is typically taken by mouth once a day. Side effects can include low red blood cells, nausea, and stomach pain. Dapsone is no longer available as a brand name, and only comes as a generic.

• Dermatitis herpetiformis
• Leprosy

• Lower red blood cell counts
• Numbness or tingling
• Muscle weakness
• Nausea and vomiting
• Stomach pain

• Blood problem (methemoglobinemia)
• Low blood cell counts
• Severe skin reactions
• Liver damage and jaundice

Retin-A (tretinoin) is a retinoid medication that's used to treat acne in adults and children 12 years and older. It's available as a cream or a gel that's applied onto the skin once a day. Side effects include skin irritation, redness, and peeling. Your acne might get worse at the beginning of treatment, but it should get better as you continue using the medication. You must have a prescription for Retin-A (tretinoin) from your primary care provider or dermatologist; this medication isn't available over the counter.

• Acne

• Skin peeling or discomfort
• Warm feeling or stinging after applying
• Skin redness
• Sensitivity to sunlight (sunburns)
• Worsening of acne in the first few weeks of treatment

• Sunburns
• Skin irritation in extreme weather
• Skin reactions