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Compare Twyneo vs. Tretinoin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Twyneo (tretinoin / benzoyl peroxide)
    Retin-a (tretinoin)
  • Twyneo (tretinoin / benzoyl peroxide)
    Retin-a (tretinoin)

  • Summary of Twyneo vs. Tretinoin

    Summary for Retinoid / antiseptic
    Prescription only

    Twyneo (tretinoin / benzoyl peroxide) is a prescription medication used to treat acne in adults and children 9 years and older. It’s the first FDA-approved treatment to safely combine two common acne-fighting ingredients: tretinoin (a retinoid) and benzoyl peroxide (an antiseptic). The medication comes as a cream that you apply once a day to the affected areas. Common side effects include redness, peeling, and dry skin.

    Summary for Retinoid
    Prescription only

    Retin-A (tretinoin) is a retinoid medication that's used to treat acne in adults and children 12 years and older. It's available as a cream or a gel that's applied onto the skin once a day. Side effects include skin irritation, redness, and peeling. Your acne might get worse at the beginning of treatment, but it should get better as you continue using the medication. You must have a prescription for Retin-A (tretinoin) from your primary care provider or dermatologist; this medication isn't available over the counter.

  • Indications of Twyneo vs. Tretinoin

    Indications for
    •Acne
    Indications for
    •Acne

  • Pros and Cons of Twyneo vs. Tretinoin

    Pros and Const for Retinoid / antiseptic
    Pros
    •Combines two medications into one product for convenience
    •Can be used by adults and children ages 9 and up
    •Only needs to be applied once a day
    Cons
    •For some people, acne improvement can take weeks to months
    •Can bleach hair and fabrics
    •Might cause your skin to become more sensitive to the sun
    Pros and Const for Retinoid
    Pros
    •Easy to apply onto your skin
    •Only need to apply once nightly
    •Available in a lower-cost generic form
    Cons
    •Makes your skin more sensitive to sunlight, which can lead to sunburns
    •Can cause your skin color to temporarily become lighter or darker
    •Might worsen your acne during the first few weeks of treatment

  • Common Side Effects of Twyneo vs. Tretinoin

    Common Side Effects for
    •Stinging, burning, or pain (11%)
    •Dryness (5%)
    •Peeling (4%)
    •Redness (4%)
    Common Side Effects for
    •Skin peeling or discomfort
    •Warm feeling or stinging after applying
    •Skin redness
    •Sensitivity to sunlight (sunburns)
    •Worsening of acne in the first few weeks of treatment

  • Warnings of Twyneo vs. Tretinoin

    Common Side Effects for
    •Serious allergic reactions
    •Skin Irritation
    •Sun sensitivity
    Common Side Effects for
    •Sunburns
    •Skin irritation in extreme weather
    •Skin reactions

  • Prices with our coupons for Twyneo vs. Tretinoin

    Learn more about Twyneo
    Learn more about Retin-a

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