Key takeaways
Twyneo (tretinoin / benzoyl peroxide) and Retin-A (tretinoin) are both topical medications that treat acne. Twyneo is a combination acne treatment that contains tretinoin and benzoyl peroxide, which helps unclog pores, reduce acne-causing bacteria, and decrease inflammation. Retin-A contains tretinoin alone, which works by increasing skin cell turnover to keep pores clear and treat existing acne. Twyneo is FDA approved to treat acne in people ages 9 and older, while Retin-A is approved for acne in people ages 10 and older (ages may vary slightly by formulation). Both medications are typically applied once daily and can cause dryness, redness, and peeling, especially when treatment begins. The choice between them often depends on acne severity and skin sensitivity.
