Key takeaways
Epiduo (adapalene/benzoyl peroxide) and Minocin (minocycline) are both used to treat acne, but they work in different ways and have different uses. Epiduo is a topical gel that combines a retinoid (adapalene) and a topical antibiotic (benzoyl peroxide) to reduce pimples and skin inflammation. You apply it directly to the skin once a day. Minocin, on the other hand, is an oral antibiotic that treats acne from the inside by reducing the bacteria that cause acne. It is taken by mouth and can also treat a variety of bacterial infections, such as UTIs and respiratory infections. Epiduo can cause skin dryness and irritation, while Minocin can cause dizziness. Both can make your skin more sensitive to the sun, but Minocin can interact with birth control pills and blood thinners.
