Key takeaways
Erygel (erythromycin) and Differin gel (adapalene) are both topical treatments for acne, but they work in different ways. Erygel is a macrolide antibiotic that targets acne-causing bacteria, while Differin is a retinoid that helps renew skin cells and unclog pores. Erygel is available only by prescription, whereas Differin can be found both over-the-counter and by prescription, depending on the strength. Erygel can take 6 to 8 weeks to show results, while Differin might take up to 12 weeks. Erygel is safe to use during pregnancy, but Differin should be avoided if you are pregnant or planning to become pregnant. Both medications can cause skin irritation, but Differin also increases your sensitivity to the sun, so you need to use sunscreen. Erygel is known to cause bacterial resistance if overused, while Differin can make your skin look worse before it gets better.
