Key takeaways
Adapalene (Differin) and benzoyl peroxide (BenzeFoam) are both topical medications used to treat acne. However, they belong to different medication classes and work in distinct ways. Adapalene is a retinoid that helps replace old skin cells with new ones, unclogging pores and reducing inflammation. Benzoyl peroxide is an antiseptic that prevents acne-causing bacteria from growing. Adapalene is typically applied once daily at bedtime, while benzoyl peroxide can be used 1 to 3 times daily, depending on your prescriber's instructions. Differin is available both over-the-counter and by prescription, while BenzeFoam is a prescription-only product. Common side effects of adapalene include dry skin, redness, and stinging, while benzoyl peroxide can cause redness, burning, and peeling. Both medications can make your skin more sensitive to sunlight, so using sunscreen is important. Additionally, benzoyl peroxide can bleach hair and clothing, so you should wash your hands after applying it.
