Key takeaways
Benzoyl peroxide (brands like PanOxyl and Neutrogena Clear Pore) and salicylic acid (brands like Salex and Keralyt) are both topical medications used to treat acne. However, they belong to different medication classes and have distinct mechanisms of action. Benzoyl peroxide is an antiseptic that prevents acne-causing bacteria from growing, while salicylic acid is a keratolytic agent that exfoliates the skin and unclogs pores. Benzoyl peroxide is available over-the-counter in various forms like gels and creams, and is typically applied 1 to 3 times daily. Salicylic acid also comes in multiple forms, such as creams and shampoos, and is used for a wider range of skin conditions, including warts and dandruff, with dosing varying by condition. Both medications can cause skin irritation, but benzoyl peroxide may bleach hair and clothing, while salicylic acid carries risks like Reye's syndrome in children and salicylate toxicity. Benzoyl peroxide is not recommended for sensitive skin, whereas salicylic acid should be used cautiously in people with diabetes or poor blood flow.
