Key takeaways
Adapalene/benzoyl peroxide (Epiduo, Epiduo Forte) and tretinoin (Retin-A) are both retinoids, which are forms of vitamin A, but there are some differences. Adapalene/benzoyl peroxide is a topical medication used to treat acne in people 9 years and older, while tretinoin (Retin-A) is an topical medication used to treat acne in adults and children 12 years and older. Adapalene/benzoyl peroxide is applied once daily as a gel, while Tretinoin (Retin-A) is available as a cream or a gel. Both medications are available as a lower-cost generic. Adapalene/benzoyl peroxide can cause side effects like dry skin and irritation, while tretinoin can cause skin irritation, redness, and peeling. Tretinoin may cause your acne to get worse at the beginning of treatment, but it should get better as you continue using the medication.
