Head-to-head comparisons of medication uses, side effects, warnings, and more.
Twyneo (tretinoin / benzoyl peroxide)
Epiduo (adapalene / benzoyl peroxide)
Twyneo (tretinoin / benzoyl peroxide)
Epiduo (adapalene / benzoyl peroxide)
Summary of Twyneo vs. Epiduo
Summary for Retinoid / antiseptic
Prescription only
Twyneo (tretinoin / benzoyl peroxide) is a prescription medication used to treat acne in adults and children 9 years and older. It’s the first FDA-approved treatment to safely combine two common acne-fighting ingredients: tretinoin (a retinoid) and benzoyl peroxide (an antiseptic). The medication comes as a cream that you apply once a day to the affected areas. Common side effects include redness, peeling, and dry skin.
Summary for Retinoid / Topical antibiotic
Prescription only
Epiduo (adapalene / benzoyl peroxide) is a topical gel that contains two active ingredients: adapalene (a retinoid) and benzoyl peroxide (an antiseptic). It's FDA approved to treat acne (pimples) in adults and children. The gel is typically applied to the skin once a day. Side effects aren't common, but can include dry skin, skin irritation, and skin burning. The medication is available as a generic and under two brand names: Epiduo and Epiduo Forte.