Key takeaways
Twyneo (tretinoin / benzoyl peroxide) and Epiduo (adapalene / benzoyl peroxide) are both topical medications used to treat acne in people 9 years and older. They belong to the retinoid and antiseptic drug classes. While both medications combine a retinoid with benzoyl peroxide, they differ in their specific retinoid components: Twyneo contains tretinoin, while Epiduo contains adapalene. Twyneo is available only as a brand-name product, whereas Epiduo is available as both a brand-name and a lower-cost generic option. Both medications are applied once daily, but Twyneo comes as a cream, and Epiduo is a gel. Common side effects for both include skin irritation, dryness, and increased sensitivity to sunlight. However, Twyneo may cause more severe allergic reactions, while Epiduo can cause skin scaling and redness. Both medications can bleach hair and fabrics, so you should wash your hands after applying them.
