Key takeaways
Adapalene (Differin) and tretinoin (Retin-A, Atralin, Avita) are both retinoids used for acne and wrinkles. Adapalene is available over-the-counter and by prescription, whereas tretinoin (Retin-A) is available only by prescription. They both work by replacing old skin cells with new ones, helping to unclog pores and reducing inflammation, although tretinoin has higher potency due to its broader receptor binding. While both medications can cause skin irritation, tretinoin has more severe side effects, including headaches, dizziness, and a risk of blood clots. Adapalene is generally considered less irritating to the skin compared to tretinoin. Additionally, tretinoin requires strict birth control measures due to its high risk of causing birth defects, whereas adapalene's safety during pregnancy is less clear but still warrants caution.
