Key takeaways
Azelaic acid (Finacea, Azelex) and doxycycline hyclate are both used to treat acne, but they work in different ways. Azelaic acid is a topical antibacterial medication that you apply to your skin to treat mild to moderate acne and rosacea. It works by stopping the growth of certain bacteria and reducing inflammation. You need to use it twice daily, and it may take several weeks to see improvement. On the other hand, doxycycline hyclate is an oral antibiotic that treats a wide range of bacterial infections, including severe acne, respiratory infections, and sexually transmitted infections. It works by preventing bacteria from making proteins they need to grow. Doxycycline hyclate is taken by mouth once or twice daily, and it can cause side effects like stomach upset and increased sensitivity to the sun. Unlike azelaic acid, doxycycline hyclate is not safe for young children or pregnant women due to risks like permanent tooth discoloration and harm to unborn babies. Azelaic acid is available in gel, foam, and cream forms, while doxycycline hyclate comes in capsules, tablets, and liquid syrup.
