Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Azelaic acid (Finacea, Azelex) and doxycycline hyclate are both used to treat acne, but they work in different ways. Azelaic acid is a topical antibacterial medication that you apply to your skin to treat mild to moderate acne and rosacea. It works by stopping the growth of certain bacteria and reducing inflammation. You need to use it twice daily, and it may take several weeks to see improvement. On the other hand, doxycycline hyclate is an oral antibiotic that treats a wide range of bacterial infections, including severe acne, respiratory infections, and sexually transmitted infections. It works by preventing bacteria from making proteins they need to grow. Doxycycline hyclate is taken by mouth once or twice daily, and it can cause side effects like stomach upset and increased sensitivity to the sun. Unlike azelaic acid, doxycycline hyclate is not safe for young children or pregnant women due to risks like permanent tooth discoloration and harm to unborn babies. Azelaic acid is available in gel, foam, and cream forms, while doxycycline hyclate comes in capsules, tablets, and liquid syrup.
Azelaic acid (Finacea)
Doxycycline hyclate
Azelaic acid (Finacea)
Doxycycline hyclate
Summary of Finacea vs. Vibramycin
Summary for Dicarboxylic acid
Prescription only
Azelaic acid (Finacea) is a dicarboxylic acid. It's a topical medication used to treat mild-to-moderate rosacea in adults. It works by easing skin redness and inflammation. Azelaic acid (Finacea) is applied to the skin twice daily, in the morning and evening. This medication comes as a gel and foam. Some side effects of azelaic acid (Finacea) include mild burning, tingling, and itching. It's available as brand name and generic medications.
•Treatment of papules and pustules in adults with mild-to-moderate rosacea
Indications for
Doxycycline hyclate is used to prevent malaria due to the parasite Plasmodium falciparum and to treat many different infections caused by bacteria. Some examples include:
•Respiratory tract infections, including in the nose, throat, and lungs
•Infections caused by ticks, mites, or fleas (Rocky Mountain spotted fever or typhus fever)
•Sexually-transmitted infections (STIs) like chlamydia, gonorrhea, chancroid, and syphilis
•Lyme disease
•Urinary tract infections (UTIs)
•Severe acne
•Anthrax
•Plague
•Cholera
Pros and Cons of Finacea vs. Vibramycin
Pros and Const for Dicarboxylic acid
Pros
•Available as a gel and foam
•Applied to the skin; convenient for people who don't like pills
•Can wear cosmetics after it dries
Cons
•Might take months to see improvement
•Can cause skin irritation, such as burning or dryness
•Can cause skin color to lighten
Pros and Const for Tetracycline antibiotic
Pros
•Good alternative for some infections if you're allergic to penicillins