Compare Renova vs. Ziana

Renova (Tretinoin) and Ziana (clindamycin/tretinoin) are both topical medications, but they are used for different purposes. Renova is primarily used to lessen fine wrinkles on your face, while Ziana is used to treat acne in people over 12 years old. Renova contains only tretinoin, a retinoic acid derivative that helps the skin renew itself, whereas Ziana combines tretinoin with clindamycin, an antibiotic that kills acne-causing bacteria. Both medications require a prescription and can cause skin irritation and increased sensitivity to the sun. While it’s less likely to happen with topical medications than oral pills, severe diarrhea can happen with Ziana if too much is absorbed. Neither medication should be used during pregnancy. Additionally, Ziana should be avoided if you have certain bowel conditions like Crohn's disease or ulcerative colitis. While several forms of tretinoin are available as generics, Renova (which is 0.02% tretinoin) is only available as a brand name cream. A generic of Ziana is available but can still be expensive.