Key takeaways
Cleocin (clindamycin) and Zithromax (azithromycin) are both antibiotics, but they belong to different classes and treat different types of infections. Cleocin (clindamycin) is a lincosamide antibiotic used as a vaginal suppository to treat bacterial vaginosis, while Zithromax (azithromycin) is a macrolide antibiotic taken orally to treat various infections like strep throat, sinus infections, and pneumonia. Cleocin (clindamycin) is only available as a brand-name medication, making it more expensive, whereas Zithromax (azithromycin) is available as a lower-cost generic. Cleocin (clindamycin) is typically used for a short 3-day course, while Zithromax (azithromycin) treatment can last from 3 to 5 days depending on the infection. Cleocin (clindamycin) can cause local side effects like vaginal irritation and yeast infections, whereas Zithromax (azithromycin) can cause stomach-related side effects like diarrhea and nausea. Additionally, Zithromax (azithromycin) has potential risks for heart rhythm problems and liver damage, which are not associated with Cleocin (clindamycin).
