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Zyvox vs. Cleocin T

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Linezolid (Zyvox) and Cleocin (clindamycin) are both antibiotics, but they are used to treat different types of infections and come in different forms. Linezolid is an oxazolidinone antibiotic available as a tablet, powder for suspension, and injection, and it treats serious bacterial infections like pneumonia and MRSA. It works by stopping bacteria from making proteins, which prevents them from growing. On the other hand, Cleocin is a lincosamide antibiotic used as a vaginal suppository to treat bacterial vaginosis. It also stops bacteria from making proteins but is specifically designed for vaginal use. Linezolid can cause serious side effects like serotonin syndrome and low blood cell counts, while Cleocin can cause vaginal yeast infections and severe diarrhea. Additionally, Cleocin is only available as a brand-name medication, making it potentially more expensive, whereas Linezolid has both brand and generic forms.

Linezolid

(Zyvox)

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Clindamycin

(Cleocin-T)

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Summary for Zyvox

Prescription only

Linezolid (Zyvox) is an oxazolidinone antibiotic that's used to treat adults and children with certain bacterial infections, such as pneumonia and skin infections. This antibiotic can help fight hard-to-treat infections caused by certain bacteria, such as MRSA and VRE. Linezolid (Zyvox) is available as a tablet, powder for suspension, and injection. It's typically taken every 8 or 12 hours. Some side effects include nausea, diarrhea, and headache. This antibiotic also has a rare but serious risk for serotonin syndrome from interactions with medications like antidepressants.

Indications for Zyvox

Pros and Cons for Zyvox

Pros

  • Good choice for treating infections caused by resistant bacteria like MRSA and VRE
  • Available as a tablet, powder for suspension, and injection
  • Can be used in people with kidney or liver problems

Cons

  • Need to take every 8 or 12 hours, depending on your age and infection
  • Can raise the risk of serotonin syndrome when taken with other medications that affect serotonin levels in the body
  • Interacts with some foods, such as aged cheeses, cured meats, and pickled foods

Common Side Effects for Zyvox

Adults

  • Diarrhea (8%)
  • Nausea (7%)
  • Headache (6%)

Children

  • Diarrhea (11%)
  • Vomiting (9%)
  • Anemia (low red blood cell count; 6%)
  • Low platelets (up to 5%)

Warnings for Zyvox

  • Low blood cell counts
  • Nerve and eye damage
  • Serotonin syndrome
  • Diarrhea from Clostridioides difficile infection
  • Buildup of lactic acid in the blood (lactic acidosis)
  • Seizures
  • Low blood sugar
  • Low blood sodium levels
  • Caution use in people with phenylketonuria (PKU) - powder for suspension form only

Summary for Cleocin T

Prescription only

Clindamycin (Cleocin-T) is a topical antibiotic that is used to treat mild to moderate acne. When combined with other acne medications like benzoyl peroxide or retinoids like Retin-A, it can work quite well to treat acne. It's also available in many different formulations like lotion, gel, and solution.

Indications for Cleocin T

  • Acne

Pros and Cons for Cleocin T

Pros

  • Available in generic form
  • Comes in different formulations (gel, solution, lotion, foam, swabs) to fit your lifestyle and perference
  • Works well for the kind of acne that causes large, red, and swollen pimples
  • Usually the first choice acne treatment for mild to moderate acne
  • There are prescription medications available that contain clindamycin combined with other popular acne medications like benzoyl peroxide or retinoid.

Cons

  • You will most likely have to use another acne medication along with clindamycin (Cleocin-T) since it doesn't work as well by itself.
  • It's only preferred for mild to moderate acne. If you have severe acne, your healthcare provider will most likely prescribe an oral medication.
  • If you only have comedonal acne (small skin-colored bumps on the skin) without any red, swollen pimples, your healthcare provider may give you a different medication.
  • Topical clindamycin (Cleocin-T) won't cure your acne, but it will help keep your acne under control.
  • You may need to use this medication for many weeks until you see your acne get better.

Common Side Effects for Cleocin T

  • Skin irritation
  • Dryness
  • Redness
  • Peeling
  • Burning
  • Oily skin
  • Skin that's sensitive to the sun

Warnings for Cleocin T

  • SKIN IRRITATION
  • SEVERE DIARRHEA AND STOMACH CRAMPS
  • SUN SENSITIVITY

Prices with our coupons for Zyvox vs. Cleocin T

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Linezolid20 tablets / 600mg
$41.46$2,649.82
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Clindamycin21 capsules / 300mg
$14.57-
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