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Flagyl vs. Malarone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Metronidazole (Flagyl) and Malarone (atovaquone/proguanil) are both prescription medications, but they treat different types of infections. Metronidazole is an antibiotic used to treat various bacterial and parasitic infections, such as bacterial vaginosis and trichomoniasis. It is taken multiple times a day and has a generic form available, making it a lower-cost option. On the other hand, Malarone is an antimalarial medication used to prevent and treat malaria. It is taken once a day and is not available in a generic form. Metronidazole has a serious interaction with alcohol and can cause a metallic taste in your mouth, while Malarone is generally well-tolerated but can cause vivid dreams and liver problems. Additionally, Malarone is not recommended for people with severe kidney or liver problems, or for pregnant or breastfeeding women.

Metronidazole

(Flagyl)

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Malarone

(atovaquone / proguanil)

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Summary for Flagyl

Prescription only

Metronidazole (Flagyl) is an oral antibiotic for adults and children. It's used to treat certain bacterial and parasitic infections, including bacterial vaginosis (a type of vaginal bacteria infection) and trichomoniasis (a sexually transmitted infection, or STI). Metronidazole (Flagyl) is taken by mouth, typically 3 times a day. Some common side effects of this medication include diarrhea, nausea, and vomiting. Avoid drinking alcohol while taking and for 3 days after stopping metronidazole (Flagyl) because this combination can cause a serious reaction. Metronidazole (Flagyl) is available as a lower-cost generic.

Indications for Flagyl

Treatment of certain bacterial and parasitic infections, including:

Pros and Cons for Flagyl

Pros

  • Taken by mouth
  • Available as a lower-cost generic medication
  • Can be used to treat different types of bacterial infection
  • Immediate-release formulations can be taken with or without food

Cons

Common Side Effects for Flagyl

Please note: These are common side effects reported by people who took extended-release metronidazole (Flagyl)

  • Headache (18%)
  • Inflammation of the vagina (15%)
  • Nausea (10%)
  • Metallic taste (9%)
  • Flu-like symptoms (6%)

Warnings for Flagyl

  • Possible risk of cancer
  • Serious allergic reactions
  • Brain and nerve problems
  • Liver and kidney problems
  • Risk of fungal infection
  • Risk of drug resistance
  • Lower white blood cell counts
  • Interaction with other medications

Summary for Malarone

Prescription only

Malarone (atovaquone / proguanil) is a CDC-recommended medication to help prevent and treat malaria. This combination medication is taken by mouth once per day. It doesn't have many side effects and can be used in children and adults.

Indications for Malarone

  • Prevention and treatment of malaria caused by Plasmodium falciparum species

Pros and Cons for Malarone

Pros

  • Works well for preventing and treating malaria
  • Can use for traveling to areas known to have resistance to chloroquine, another antimalarial medication
  • Good choice for shorter trips because you only have to take it for 1 more week after leaving from the malaria area, rather than for 4 more weeks with other malaria medications (e.g., mefloquine, chloroquine)
  • Has relatively few side effects

Cons

  • Not the best choice for people with severe kidney or liver problems
  • Not recommended for pregnant or breastfeeding females
  • Taken once per day (compared to other antimalarial medications that are taken once per week)

Common Side Effects for Malarone

  • Stomach pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Low appetite
  • Headache
  • Weakness
  • Dizziness

Warnings for Malarone

  • Worsening infection
  • Liver damage

Prices with our coupons for Flagyl vs. Malarone

Price Card Drug Icon
Metronidazole14 tablets / 500mg
$10.73$14.75
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Price Card Drug Icon
Atovaquone/Proguanil30 tablets / 250mg/100mg
$49.22$69.63
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