What is Mefloquine?

Commonly Used Brand Name(s)Lariam

Therapeutic ClassificationsAntimalarial

Blackbox WarningTOP

Oral route (Tablet)

Mefloquine may cause neuropsychiatric adverse reactions that can persist after mefloquine has been discontinued. Mefloquine should not be prescribed for prophylaxis in patients with major psychiatric disorders. During prophylactic use, if psychiatric or neurologic symptoms occur, the drug should be discontinued and an alternative medication should be substituted

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OverviewTOP

Mefloquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines (eg, chloroquine) may not work.

Mefloquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito.

Malaria transmission occurs in large areas of Central and South America, Hispaniola, sub-Saharan Africa, the Indian subcontinent, Southeast Asia, the Middle East, and Oceania. Country-specific information on malaria can be obtained from the Centers for Disease Control and Prevention (CDC), or from the CDC's web site at http://www.cdc.gov/travel.

This medicine is available only with your doctor's prescription.

Proper UseTOP

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide and an information wallet card. Read and follow the instructions carefully. Talk with your doctor if you have any questions.

Mefloquine is best taken with a full glass (8 ounces) of water and with food, unless otherwise directed by your doctor.

Mefloquine may be crushed and put in water, milk, or juice to make it easier to take.

For patients taking mefloquine to prevent the symptoms of malaria:

Your doctor will want you to start taking this medicine one week before you travel to an area where there is a chance of getting malaria.
Also, you should keep taking this medicine while you are in the area where malaria is present and for 4 weeks after you leave the area. No medicine will protect you completely from malaria. However, to protect you as completely as possible, it is important that you keep taking this medicine for the full time your doctor ordered. Also, if fever or “flu-like” symptoms develop during your travels or within 2 to 3 months after you leave the area, check with your doctor immediately.
This medicine works best when you take it on a regular schedule. For example, if you are to take it once a week, it is best to take it on the same day each week. Do not miss any doses. If you have any questions about this, check with your doctor.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Children may vomit after taking this medicine. Your child may vomit some of the dose of medicine. Contact your child's doctor if vomiting occurs. The doctor may need for you to give your child more medicine.

The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on whether you are using mefloquine to prevent or to treat malaria.

DosingTOP

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For treatment of malaria:
  - Adults—1250 milligrams (mg) or five tablets as a single dose.
  - Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The usual dose is 20 to 25 mg per kg of body weight as a single dose or two doses (divide the single dose by two) taken 6 to 8 hours apart. Taking two doses may decrease the occurrence of unwanted side effects.
  - Children younger than 6 months of age—Use and dose must be determined by your doctor.
- For prevention of malaria:
  - Adults and children weighing over 45 kilograms (kg)—250 milligrams (mg) (1 tablet) 1 week before traveling to an area where malaria occurs. Then, 250 mg once a week on the same day of each week and preferably after your main meal while staying in the area and every week for 4 weeks after leaving the area.
  - Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor.
    - Children weighing 30 to 45 kg: 187.5 mg (¾ tablet) 1 week before traveling to an area where malaria occurs. Then, 187.5 mg once a week while staying in the area and every week for 4 weeks after leaving the area.
    - Children weighing 20 to 30 kg: 125 mg (½ tablet) 1 week before traveling to an area where malaria occurs. Then, 125 mg once a week while staying in the area and every week for 4 weeks after leaving the area.
    - Children weighing 10 to 19 kg: 62.5 mg (¼ tablet) 1 week before traveling to an area where malaria occurs. Then, 62.5 mg once a week while staying in the area where malaria occurs and every week for 4 weeks after leaving the area.
    - Children weighing 5 to 9 kg: 5 mg per kg of body weight 1 week before traveling to an area where malaria occurs.
  - Children younger than 6 months of age and weighing less than 5 kg—Use and dose must be determined by your doctor.

Missed DoseTOP

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Use & StorageTOP

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Before UsingTOP

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

AllergiesTOP

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

PediatricTOP

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of mefloquine in children. However, safety and efficacy have not been established in children younger than 6 months of age.

GeriatricTOP

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mefloquine in the elderly. However, elderly patients are more likely to have age-related heart problems, which may require caution in patients receiving mefloquine.

PregnancyTOP

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast FeedingTOP

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug InteractionsTOP

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine
Amisulpride
Aurothioglucose
Bepridil
Cisapride
Dronedarone
Fluconazole
Isradipine
Ketoconazole
Levomethadyl
Mesoridazine
Nelfinavir
Pimozide
Piperaquine
Posaconazole
Saquinavir
Sparfloxacin
Terfenadine
Thioridazine
Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide
Ajmaline
Alfuzosin
Amiodarone
Amitriptyline
Amoxapine
Anagrelide
Apomorphine
Aprindine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Azimilide
Azithromycin
Bretylium
Buprenorphine
Buserelin
Ceritinib
Chloral Hydrate
Chloroquine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clozapine
Crizotinib
Dabrafenib
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Droperidol
Efavirenz
Enflurane
Erythromycin
Escitalopram
Fingolimod
Flecainide
Fluoxetine
Foscarnet
Gatifloxacin
Gemifloxacin
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Halothane
Histrelin
Hydroquinidine
Hydroxychloroquine
Hydroxyzine
Ibutilide
Idelalisib
Iloperidone
Imipramine
Inotuzumab Ozogamicin
Isoflurane
Ivabradine
Lapatinib
Leuprolide
Levofloxacin
Lidoflazine
Lofexidine
Lopinavir
Lorcainide
Macimorelin
Methadone
Metronidazole
Mifepristone
Moxifloxacin
Nafarelin
Nilotinib
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Ondansetron
Osimertinib
Paliperidone
Panobinostat
Pasireotide
Pazopanib
Pentamidine
Pimavanserin
Pirmenol
Pitolisant
Prajmaline
Probucol
Procainamide
Prochlorperazine
Promethazine
Propafenone
Propranolol
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Ribociclib
Risperidone
Salmeterol
Sematilide
Sertindole
Sertraline
Sevoflurane
Sodium Phosphate
Sodium Phosphate, Dibasic
Sodium Phosphate, Monobasic
Solifenacin
Sorafenib
Sotalol
Spiramycin
Sulfamethoxazole
Sulpiride
Sultopride
Sunitinib
Tacrolimus
Tedisamil
Telavancin
Telithromycin
Tetrabenazine
Tizanidine
Toremifene
Trazodone
Trifluoperazine
Trimethoprim
Trimipramine
Triptorelin
Vandetanib
Vardenafil
Vasopressin
Vemurafenib
Vinflunine
Voriconazole
Zolmitriptan
Zotepine
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Lumefantrine
Rifampin
Valproic Acid

Other InteractionsTOP

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

PrecautionsTOP

It is important that your doctor check your or your child's progress after treatment. This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Do not take halofantrine (Halfan®) or ketoconazole (Nizoral®) with mefloquine or within 15 weeks after the last dose of this medicine. This may increase the risk for more serious problems.

Contact your doctor right away if you or your child have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Tell your doctor right away if you or your child are feeling anxious, confused, depressed, restless, or having unusual thoughts or behavior after using mefloquine.

Check with your doctor right away if you have the following symptoms after taking this medicine: dizziness, feeling of constant movement of self or surroundings, seizures, or trouble sleeping. These symptoms may continue to occur for months or years after stopping treatment with mefloquine.

Check with your doctor right away if you or your child have flu-like symptoms (such as chills, fever, headache, or muscle pains) again after treatment with this medicine.

Use birth control pills while you are taking this medicine and for 3 months after stopping it. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may cause serious allergic reactions. Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Mefloquine may cause vision problems. It may also cause some people to become dizzy or lightheaded, lose your balance, or to have hallucinations (seeing, hearing, or feeling things that are not there). Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. This is especially important for people whose jobs require fine coordination. If these reactions are especially bothersome, check with your doctor.

Check with your doctor immediately if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).

While you are being treated with mefloquine, do not have any immunizations (vaccinations) without your doctor's approval. Live virus vaccines should be completed 3 days before the first dose of this medicine.

Malaria is spread by the bites of certain kinds of infected female mosquitoes. If you are living in or will be traveling to an area where there is a chance of getting malaria, the following mosquito-control measures will help to prevent infection:

If possible, avoid going out between dusk and dawn because it is at these times that mosquitoes most commonly bite.
Wear long-sleeved shirts or blouses and long trousers to protect your arms and legs, especially from dusk through dawn when mosquitoes are out.
Apply insect repellant, preferably one containing DEET, to uncovered areas of the skin from dusk through dawn when mosquitoes are out.
If possible, sleep in a screened or air-conditioned room or under mosquito netting sprayed with insecticide to avoid being bitten by malaria-carrying mosquitoes.
Use mosquito coils or sprays to kill mosquitoes in living and sleeping quarters during evening and nighttime hours.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.