Primaquine

Before taking Primaquine, your healthcare provider might test you for a genetic condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency. People with G6PD deficiency who take Primaquine have a higher risk of low red blood cell counts (hemolytic anemia). This is when your red blood cells get destroyed faster than your body is able to make new ones. Discuss the risks and benefits of taking this medication if you have G6PD deficiency. You might be able to take Primaquine with close monitoring of your blood cell counts through regular blood work. Don't take Primaquine if you have severe G6PD deficiency. Stop the medication and let your provider know right away if you experience dark urine, tiredness, weakness, dizziness, or pale skin, as these can be signs of hemolytic anemia.

Primaquine can cause blood problems, including a low white blood cell count, low red blood cell count, and destruction of red blood cells. This risk is higher if you have a personal or family history of blood problems, a certain genetic condition called NADH methemoglobin reductase deficiency, or take Primaquine for a long period of time. Before you take this medication, let your healthcare provider know your full medical history. Don't take Primaquine longer than prescribed. Your healthcare provider might check your blood levels every so often while you're taking this medication to make sure they're within normal range. Let your provider know if you're getting sick more often (sign of a low white blood cell count) or experiencing dark urine, tiredness, weakness, dizziness, or pale skin (signs of hemolytic anemia).