Head-to-head comparisons of medication uses, side effects, warnings, and more.
Primaquine
Quinine (Qualaquin)
Primaquine
Quinine (Qualaquin)
Summary of Primaquine vs. Qualaquin
Summary for Antimalarial
Prescription only
Primaquine helps treat certain types of malaria. It's also commonly used for prevention of malaria if you're traveling to a region where the disease is commonly found. This medication can cause stomach upset, nausea, and diarrhea.
Summary for Antimalarial
Prescription only
Quinine (Qualaquin) is used to treat malaria in people ages 16 years and older. It's not used for preventing malaria. It's available as a capsule taken every 8 hours. Side effects of quinine (Qualaquin) include nausea, stomach pain, and vomiting. Taking it with food can ease some stomach-related side effects. It's typically not a first-choice option because it has a lot of side effects, drug interactions, and needs to be taken in combination with either doxycycline (Vibramycin, Doryx) or certain other antimalarial medications.
Indications of Primaquine vs. Qualaquin
Indications for
•Malaria caused by the Plasmodium vivax parasite
Indications for
•Treatment of uncomplicated malaria caused by Plasmodium falciparum in people ages 16 years and older
Pros and Cons of Primaquine vs. Qualaquin
Pros and Const for Antimalarial
Pros
•Good choice to treat certain types of malaria
•Taken only once a day
•Good for last minute travelers for malaria prevention; can start the medication 1 to 2 days before traveling
Cons
•Must be tested for a genetic condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency before starting
•Can cause stomach upset
•Can't be used in pregnancy
Pros and Const for Antimalarial
Pros
•Only need to take for a week to treat malaria
•Taken by mouth
•Available as a lower-cost generic
Cons
•Taken every 8 hours
•Only available as a capsule
•Interacts with a lot of medications, including certain antiseizure medications and antibiotics
Common Side Effects of Primaquine vs. Qualaquin
Common Side Effects for
•Nausea
•Vomiting
•Stomach pain or cramps
•Dizziness
Common Side Effects for
•Headache
•Sweating
•Ringing in the ears
•Hearing loss
•Dizziness
•Blurry vision
•Changes in how you see color
Warnings of Primaquine vs. Qualaquin
Common Side Effects for
•Low red blood cell counts in people with G6PD deficiency
•Blood problems
•Heart rhythm problems
Common Side Effects for
•Not for leg cramps
•Low platelet counts (thrombocytopenia)
•Hemolytic anemia (low red blood cells)
•Life-threatening abnormal heart rhythm
•Low blood sugar
•Severe skin and allergic reactions
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