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Compare Augmentin vs. Cipro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Augmentin (amoxicillin/clavulanate) and Cipro (ciprofloxacin) are both antibiotics used to treat bacterial infections, but they belong to different drug classes and have distinct uses and side effects. Augmentin is a combination of a penicillin antibiotic and a beta-lactamase inhibitor, making it effective against bacteria that can resist amoxicillin alone. It is commonly used for ear, sinus, respiratory, skin, and urinary tract infections. Cipro, on the other hand, is a fluoroquinolone antibiotic that works by blocking enzymes bacteria need to grow and repair their DNA. It is used for more serious infections like bone, joint, and lower respiratory tract infections, and is also an option for those allergic to penicillin. While both medications can cause diarrhea and nausea, Cipro has more severe potential side effects, such as tendon rupture and nerve damage, and is generally reserved for cases where other antibiotics are not suitable. Additionally, Cipro can interact with many medications and requires caution with sun exposure, whereas Augmentin is safer for use during pregnancy and breastfeeding.

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