Key takeaways
Amoxicillin/clavulanate (Augmentin) and levofloxacin (Levaquin) are both antibiotics used to treat bacterial infections, including sinus infections and urinary tract infections (UTIs). However, they belong to different medication classes. Amoxicillin-clavulanate is a penicillin antibiotic combined with a beta-lactamase inhibitor, while levofloxacin is a fluoroquinolone antibiotic. Amoxicillin-clavulanate is available in various forms, such as tablets, chewable tablets, and oral suspension, and is typically taken two to three times daily. In contrast, levofloxacin is usually taken once daily and is available as tablets, oral liquid, and injection. Both medications are available as lower-cost generics. Common side effects of amoxicillin-clavulanate include diarrhea, nausea, and rash, whereas levofloxacin can cause nausea, headache, and diarrhea, along with more serious risks like tendon rupture and nerve damage. Both medications can interact with other drugs, but levofloxacin has a broader range of potential interactions, including with antacids and multivitamins.
