Key takeaways
Clindamycin (Cleocin) and Augmentin (amoxicillin/clavulanate) are both antibiotics used to treat bacterial infections, including skin and lower respiratory tract infections. However, they belong to different medication classes. Clindamycin is a lincosamide antibiotic, while Augmentin combines a penicillin antibiotic with a beta-lactamase inhibitor. Clindamycin is available in oral capsules, liquid, and injection forms, and is typically taken three to four times a day. Augmentin comes in tablets, chewable tablets, and liquid suspension, usually taken two to three times daily. Both medications have generic versions available, making them more affordable. Common side effects of clindamycin include stomach upset, itching, and rash, while Augmentin may cause diarrhea, nausea, and rash. Both medications can cause serious allergic reactions and *Clostridioides difficile* (C. diff) infections, but Augmentin also carries a risk of liver damage. Clindamycin can be used if you have a penicillin allergy, whereas Augmentin should be avoided if you have a severe penicillin allergy.
