Key takeaways
Cefdinir (Omnicef) and clindamycin (Cleocin) are both antibiotics used to treat bacterial infections, including skin infections and strep throat. However, they belong to different medication classes. Cefdinir is a cephalosporin antibiotic, while clindamycin is a lincosamide antibiotic. Cefdinir is available as capsules and oral suspension, typically taken once or twice a day, and is also used off-label for urinary tract infections in children. Clindamycin comes in capsules, liquid, and injection forms, and is taken three or four times a day. Clindamycin is also used for more severe infections like bone and joint infections. Both medications can cause diarrhea, but clindamycin has a higher risk of causing serious *Clostridioides difficile* infections. Cefdinir may interact with warfarin, antacids and iron supplements, while clindamycin can interact with medications like warfarin and certain seizure medications. Generic versions of both medications are available, but clindamycin is generally cheaper.
