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Mefloquine

Mefloquine Side Effects

Dalga Surofchy, PharmD, APhMichelle Nguyen, PharmD
Reviewed by Dalga Surofchy, PharmD, APh, Michelle Nguyen, PharmD
Last reviewed on June 29, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Most common side effects when used for treatment of malaria:

  • Dizziness
  • Muscle pain
  • Stomach pain
  • Nausea
  • Headache
  • Vomiting
  • Diarrhea
  • Skin rash
  • Fever
  • Chills
  • Tiredness
  • Loss of appetite
  • Ringing sound in ears (tinnitus)

Most common side effects when used for prevention of malaria:

  • Vomiting (3%)

Less Common Side Effects

  • Dizziness
  • Sudden drop in blood pressure
  • Changes or slowing of your heart beat
  • Hair loss
  • Emotional or mood changes
  • Seizures
  • Itching
  • Tiredness

Mefloquine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Frequent episodes of fevers, tiredness, or chills (these can be signs of a sudden drop in white blood cells, which raises your risk of serious infections)
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Source: DailyMed

The following Mefloquine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Aching joints and muscles

anxiety

blistering, loosening, peeling, or redness of the skin

chest pain or discomfort

chills

confusion

convulsions (seizures)

cough or hoarseness

dizziness

fainting

fever

hallucinations (seeing, hearing, or feeling things that are not there)

irregular, pounding, slow, or fast heartbeat or pulse

irritability

lightheadedness

lower back or side pain

mental depression

painful or difficult urination

pinpoint red spots on the skin

red or irritated eye

restlessness

sore throat

sores, ulcers, or white spots in the mouth or on the lips

stiff neck

swelling of the ankles, feet, or lower legs

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

Incidence not known

Blurred or loss of vision

continuing ringing or buzzing or other unexplained noise in the ears

disturbed color perception

double vision

feeling of constant movement of self or surroundings

halos around lights

hearing loss

hearing problems

loss of balance

loss of bladder control

muscle spasm or jerking of all extremities

night blindness

overbright appearance of lights

sensation of spinning

severe or continuing headache

sudden loss of consciousness

trouble sleeping

troubled breathing

tunnel vision

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

emotional problems

nausea

stomach pain

Less common

Abnormal dreams

loss of appetite

skin rash

Rare

Loss of hair

Incidence not known

Acid or sour stomach

belching

flushing or redness of the skin

heartburn

indigestion

skin rash with a general disease

stomach discomfort, upset, or pain

swelling

unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Dalga Surofchy, PharmD, APh, is an Advanced Practicing Pharmacist working in San Diego, CA. He holds a bachelor’s degree in biology from the University of California, Berkeley and a Doctor of Pharmacy from the University of California, San Francisco.
Michelle Nguyen, PharmD, has been a clinical pharmacist for 6 years (and counting). She has a diverse skill set within managed care pharmacy, specifically in the settings of a medical group, pharmacy benefit manager (PBM), and health plan.

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