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Chloroquine Phosphate

Chloroquine Phosphate Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on March 16, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach cramps
  • Headache
  • Rash
  • Itching

Less Common Side Effects

  • Tiredness
  • Confusion
  • Anxiety
  • Hallucinations (hearing or seeing things that aren't there)
  • Muscle weakness

Chloroquine Phosphate serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Seizures
  • Changes in vision: blurry vision, only seeing half of an object, difficulty focusing, trouble seeing things at night
  • Irregular heartbeat (QT prolongation): dizziness, feeling lightheaded, blurry vision, pounding heart, fainting
  • Dangerously low blood sugar: feeling anxious, sweating, shaking, confusion, dizziness, weakness, fast heartbeat, feeling hungry, coma
  • Serious skin reactions: fever, tiredness, body aches, blistering rash, peeling skin

Source: DailyMed

The following Chloroquine Phosphate side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Anxiety

attempts at killing oneself

back, leg, or stomach pains

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

blurred or decreased vision

change in near or distance vision

chest discomfort or pain

chills

cold sweats

confusion

continuing ringing or buzzing or other unexplained noise in the ears

cough

dark urine

diarrhea

difficulty in focusing the eyes

difficulty with speaking

difficulty with swallowing

disturbed color perception

dizziness

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

double vision

drooling

fast, slow, irregular, or pounding heartbeat

feeling that others are watching you or controlling your behavior

feeling that others can hear your thoughts

feeling, seeing, or hearing things that are not there

fever

general tiredness and weakness

halos around lights

headache

hearing loss

inability to move the eyes

increased blinking or spasms of the eyelid

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

loss of balance control

lower back or side pain

muscle trembling, jerking, or stiffness

muscular pain, tenderness, wasting, or weakness

night blindness

nausea

overbright appearance of lights

painful or difficult urination

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red skin lesions, often with a purple center

red, irritated eyes

restlessness

shuffling walk

skin rash, hives, or itching

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sticking out of the tongue

stiffness of the limbs

sweating

swollen or painful glands

tightness in the chest

trouble breathing

tunnel vision

twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

uncontrolled movements, especially of the face, neck, and back

unusual bleeding or bruising

unusual tiredness or weakness

upper right abdominal or stomach pain

vomiting

yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Cold, clammy skin

decreased urine

drowsiness

dry mouth

fast, weak pulse

increased thirst

lightheadedness, dizziness, or fainting

loss of appetite

muscle pain or cramps

numbness or tingling in the hands, feet, or lips

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Change in hair color

hair loss

increased sensitivity of the skin to sunlight

redness or other discoloration of the skin

severe sunburn

stomach cramps

trouble sleeping

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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