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Compare Sivextro vs. Daptomycin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sivextro (tedizolid) and Cubicin (daptomycin) are both antibiotics used to treat skin infections, but they have some key differences. Sivextro (tedizolid) is an oxazolidinone antibiotic available only as a brand-name medication and can be taken orally or through an IV. It's typically taken once daily for 6 days. On the other hand, Cubicin (daptomycin) is a cyclic lipopeptide antibiotic that treats not only skin infections but also serious bloodstream infections. It's given as an IV injection, with the dosage and treatment length varying based on factors like age and kidney function. While Sivextro (tedizolid) is not recommended for children under 12, Cubicin (daptomycin) can be used in children as young as 1 year old. Additionally, Cubicin (daptomycin) is effective against MRSA and some other resistant bacteria, whereas Sivextro (tedizolid) is primarily used for skin infections. Both medications can cause diarrhea, but Cubicin (daptomycin) has a higher risk of severe muscle problems and kidney damage.

  • Sivextro (tedizolid)
    Daptomycin (Cubicin)
  • Sivextro (tedizolid)
    Daptomycin (Cubicin)

  • Summary of Sivextro vs. Daptomycin

    Summary for Oxazolidinone antibiotic
    Prescription only

    Sivextro (tedizolid) is an antibiotic used to treat skin infections, such as cellulitis. It's taken once daily for 6 days. Sivextro (tedizolid) is available only as a brand-name medication in tablet and intravenous (IV) forms. Some common effects of this medication include nausea, diarrhea, and vomiting.

    Summary for Cyclic lipopeptide antibiotic
    Prescription only

    Daptomycin (Cubicin) is an antibiotic that treats certain serious skin infections and bloodstream infections. It can fight against some bacteria that are hard to treat, such as methicillin-resistant Staphylococcus aureus (MRSA). Daptomycin (Cubicin) is given as a quick intravenous (IV) injection over a 2-minute period or as an IV infusion over a 30-to-60 minute period. The dosing depends on your age, weight, kidney function, the type of infection you have, and how severe it is. Common side effects include headache and diarrhea.

  • Indications of Sivextro vs. Daptomycin

    Indications for
    •Certain skin infections in adults and children ages 12 years and older
    Indications for
    •Skin infections (e.g., cellulitis)
    •Bloodstream infection caused by Staphylococcus aureus ("staph")

  • Pros and Cons of Sivextro vs. Daptomycin

    Pros and Const for Oxazolidinone antibiotic
    Pros
    •Only needs to be taken once a day
    •Total treatment lasts only 6 days
    •Less likely to cause gut-related side effects than linezolid (Zyvox), a similar medication
    Cons
    •Only approved for skin infections
    •Not for children under 12 years of age
    •Safety in pregnancy and breastfeeding females isn't well-studied
    Pros and Const for Cyclic lipopeptide antibiotic
    Pros
    •Good at treating serious skin and bloodstream infections caused by Staphylococcus bacteria ("staph" infections)
    •Can use to treat children as young as 1 year of age
    •Given once per day
    Cons
    •Needs to be given as an IV infusion over a 30-to-60 minute period
    •Not the best option for people who have severe kidney problems
    •Can cause a serious muscle problem called rhabdomyolysis

  • Common Side Effects of Sivextro vs. Daptomycin

    Common Side Effects for
    •Nausea (7%)
    •Headache (5%)
    •Diarrhea (4%)
    Common Side Effects for
    •Diarrhea (5%)
    •Headache (5%)
    •Rash (4%)
    •Abnormal liver function tests (3%)
    •Dizziness (2%)
    •Urinary tract infections (2%)
    •Low blood pressure (2%)
    •Shortness of breath (2%)

  • Warnings of Sivextro vs. Daptomycin

    Common Side Effects for
    •Diarrhea from Clostridioides difficile infection
    •Development of drug-resistant bacteria
    Common Side Effects for
    •Severe allergic reactions
    •Muscle pain and severe muscle damage
    •Kidney damage
    •Pneumonia
    •Nerve damage
    •Diarrhea from Clostridioides difficile infection
    •Development of drug-resistant bacteria

  • Prices with our coupons for Sivextro vs. Daptomycin

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