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Compare Cleocin vs. Sivextro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Cleocin (clindamycin) and Sivextro (tedizolid) are both antibiotics used to treat infections, but they belong to different medication classes and treat different types of infections. Cleocin (clindamycin) is a lincosamide antibiotic used as a vaginal suppository to treat bacterial vaginosis (BV) in females who have started their menstrual periods. It is not approved for use during pregnancy. Sivextro (tedizolid), on the other hand, is an oxazolidinone antibiotic used to treat certain skin infections in adults and children aged 12 years and older. Sivextro is not well studied in pregnancy. Cleocin is typically used once daily for 3 days, while Sivextro is taken once daily for 6 days. Cleocin is available as a generic medication, whereas Sivextro is only available as a brand-name medication. Common side effects of Cleocin include vaginal discomfort and yeast infections, while Sivextro may cause nausea, headache, and diarrhea. Both medications can cause serious diarrhea related to *Clostridioides difficile* infection, but Cleocin is more likely to cause vaginal yeast infections. Cleocin is inserted vaginally, while Sivextro is taken orally or via IV.

  • Cleocin (clindamycin) vaginal suppository
    Sivextro (tedizolid)
  • Cleocin (clindamycin) vaginal suppository
    Sivextro (tedizolid)

  • Summary of Cleocin vs. Sivextro

    Summary for Lincosamide antibiotic
    Prescription only

    Cleocin (clindamycin) vaginal ovule is an antibiotic suppository that treats bacterial vaginosis (BV), a type of vaginal infection. This medication can be prescribed for adults or adolescent females who've started their menstrual periods. But it's not approved for people who are pregnant. Cleocin (clindamycin) vaginal suppository is inserted vaginally once daily, typically at bedtime, for 3 days. Side effects aren't common, but can include vaginal discomfort, such as irritation and pain.

    Summary for Oxazolidinone antibiotic
    Prescription only

    Sivextro (tedizolid) is an antibiotic used to treat skin infections, such as cellulitis. It's taken once daily for 6 days. Sivextro (tedizolid) is available only as a brand-name medication in tablet and intravenous (IV) forms. Some common effects of this medication include nausea, diarrhea, and vomiting.

  • Indications of Cleocin vs. Sivextro

    Indications for
    •Bacterial vaginosis (BV) - vaginal bacterial infection
    Indications for
    •Certain skin infections in adults and children ages 12 years and older

  • Pros and Cons of Cleocin vs. Sivextro

    Pros and Const for Lincosamide antibiotic
    Pros
    •Only used once a day
    •Typically only used for 3 days
    •Applicator can be washed and reused for each insertion
    •Can be inserted without using an applicator
    Cons
    •Vaginal application can be uncomfortable for some people
    •Might cause vaginal yeast infections
    •Can't use condoms, diaphragms, or tampons during and up to 3 days after treatment
    •Recommended to use at bedtime to prevent medication from leaking
    Pros and Const for Oxazolidinone antibiotic
    Pros
    •Only needs to be taken once a day
    •Total treatment lasts only 6 days
    •Less likely to cause gut-related side effects than linezolid (Zyvox), a similar medication
    Cons
    •Only approved for skin infections
    •Not for children under 12 years of age
    •Safety in pregnancy and breastfeeding females isn't well-studied

  • Common Side Effects of Cleocin vs. Sivextro

    Common Side Effects for
    •Vaginal irritation (3%)
    •Vaginal pain (2%)
    •Vaginal yeast infection (2%)
    Common Side Effects for
    •Nausea (7%)
    •Headache (5%)
    •Diarrhea (4%)

  • Warnings of Cleocin vs. Sivextro

    Common Side Effects for
    •Severe diarrhea
    •Vaginal yeast infections
    •Damage to vaginal contraceptives
    Common Side Effects for
    •Diarrhea from Clostridioides difficile infection
    •Development of drug-resistant bacteria

  • Prices with our coupons for Cleocin vs. Sivextro

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