Facial wrinkles are folds or creases in the skin. It is part of the aging process. Wrinkles can also be caused by sun damage, smoking, and other causes. Treatments for wrinkles include topical skin creams, ointments, gels, surgery to stretch skin, and injections to smooth out skin. Retinoids, such as Renova and Avage, are common topical treatments for wrinkles. They help to renew skin cells.