Key takeaways
Aklief (trifarotene) and Arazlo (tazarotene) are both topical retinoids used to treat acne in people aged 9 years and older. They work by promoting new skin cell growth and reducing oil and inflammation. However, there are several differences between the two medications. Aklief (is available as a 0.005% cream, while Arazlo is a 0.045% lotion. Aklief is applied once daily in the evening, whereas Arazlo can be applied once daily at any time. Aklief and Arazlo are only available as a brand-name medications. Both medications can cause skin irritation and increase sensitivity to sunlight, but Arazlo is specifically not safe to use during pregnancy due to potential harm to an unborn baby. Additionally, Arazlo should not be used with benzoyl peroxide unless advised by a prescriber, as it can reduce Arazlo's effectiveness.
