Beta blocker / thiazide diuretic combinations are used to treat high blood pressure. These medications work by combining the effects of beta-blockers, which slow your heart rate and lower blood pressure, with thiazide-like diuretics, which help your body get rid of extra salt and water, which decreases your blood pressure. These medications are available in oral form. Examples include bisoprolol / hydrochlorothiazide (Ziac) and metoprolol / hydrochlorothiazide.