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Evotaz Coupon - Evotaz 300mg/150mg tablet

Evotaz

atazanavir and cobicistat
Used for HIV Treatment
Used for HIV Treatment

Evotaz (atazanavir / cobicistat) is a combination medication that's taken as part of an antiretroviral (ARV) regimen to treat HIV (human immunodeficiency virus). It's approved for people with HIV who weigh at least 77 pounds. Evotaz (atazanavir / cobicistat) is a tablet that's taken once a day with food. It must be taken along with other HIV ARV medications. Evotaz (atazanavir / cobicistat) can cause side effects, including rash and jaundice (yellowing of the skin or eyes).

Last reviewed on October 30, 2023
basics-icon

What is Evotaz (atazanavir / cobicistat)?

What is Evotaz (atazanavir / cobicistat) used for?

  • Treatment of HIV

How Evotaz (atazanavir / cobicistat) works

Evotaz (atazanavir / cobicistat) is a combination of two medications: atazanavir and cobicistat.

Are you looking for information on atazanavir (Reyataz) instead?

Drug Facts

Common BrandsEvotaz
Drug ClassAntiretroviral
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Evotaz (atazanavir / cobicistat)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Jaundice (yellowing of the skin or eyes; up to 6%)
  • Rash (5%)

Other Side Effects

  • Nausea
  • Diarrhea
  • Headache

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe skin reaction: red, raised skin areas, rash, blistering, peeling skin
  • Heart rhythm problems: feeling dizzy or lightheaded, feeling that your heart skips beats or is pounding
  • Kidney stone or gallstone: severe pain in the stomach or sides with nausea or vomiting, difficulty urinating, fever, bloody urine

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Gallbladder problems—severe stomach pain, nausea, vomiting, fever
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Infection—fever, chills, cough, or sore throat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Kidney stones—blood in the urine, pain or trouble passing urine, pain in the lower back or sides
  • Lipodystrophy—increased fat in the upper back or midsection, decreased fat in the face, arms, or legs
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Evotaz (atazanavir / cobicistat)

thumbs-up

Pros

Taken once a day

Combination tablet, so there are fewer pills to take

Same dose for adults and children who weigh at least 77 pounds

Can take if you have a sulfa allergy

thumbs-down

Cons

Need to take with food

Might cause jaundice (yellowing of skin or eyes)

Interacts with a lot of medications, such as certain other HIV medications, statins, and certain blood thinners

Must be separated from medications that treat heartburn and indigestion by a certain amount of time

pharmacist-tips

Pharmacist tips for Evotaz (atazanavir / cobicistat)

pharmacist
  • You can take Evotaz (atazanavir / cobicistat) anytime during the day. Just make sure it's around the same time every day and with food.

    • Always take Evotaz (atazanavir / cobicistat) with food. Tell your healthcare provider if access to food is a concern for you. There might be options and resources that your provider can help you with. Your provider might also consider switching you to an HIV medication that doesn't need to be taken with food.

      • Tell your providers and pharmacists about all the medications you're taking or planning to take. Evotaz (atazanavir / cobicistat) can interfere with how well your body gets rid of many medications. This can cause medications to build up in your body and raise your risk for side effects. There are some that you can't take with this HIV medication and others that need dose adjustments. Your providers can check for interactions and recommend how you can safely take your medications.

        • Talk to a provider or pharmacist before purchasing any over-the-counter medications for heartburn or indigestion. You can take these medications if you need to, but you'll need to follow specific instructions to separate them from when you take your Evotaz (atazanavir / cobicistat) dose. These medications can lower the amount of Evotaz (atazanavir / cobicistat) in your body and make the HIV medication work less well. Ask your provider or pharmacist for instructions on timing and dosing for heartburn medications.

          • Evotaz (atazanavir / cobicistat) isn't recommended during pregnancy because the blood levels of the HIV medication can drop and cause the medication to work less well. Talk to your provider about your plans for becoming pregnant or options for birth control. If you become pregnant while you're taking Evotaz (atazanavir / cobicistat), continue to take the medication, but schedule an appointment with your provider as soon as possible. Don't stop taking it on your own.

            faqs

            Frequently asked questions about Evotaz (atazanavir / cobicistat)

            Can I cut the Evotaz (atazanavir / cobicistat) tablet in half to make it easier to swallow?
            No, you must swallow the Evotaz (atazanavir / cobicistat) tablet whole. Don't cut, crush, or chew the tablets. The tablets are film-coated, so breaking them can affect how the medication works. Ask your provider about your options if you're having trouble swallowing the tablets whole.
            What should I do if I forget to take my dose of Evotaz (atazanavir / cobicistat)?
            In general, you should take your dose of Evotaz (atazanavir / cobicistat) as soon as you realize you've missed it, unless it's close to the time for your next scheduled dose. For example, you should take the medication within 12 hours of your regularly scheduled time. If it's been more than 12 hours, skip the missed dose and wait until your next dose to take the medication. Never double up on doses because this can raise your risk for side effects. It's important to avoid missing doses to prevent drug resistance (i.e., the infection becomes hard to treat). You can use a reminder app on your phone or make it a part of your daily routine to help you remember.
            Can I take Evotaz (atazanavir / cobicistat) if I have diabetes?
            Yes, but keep in mind that Evotaz (atazanavir / cobicistat) can raise your blood sugar levels and potentially worsen diabetes. Talk with your provider about whether this medication is right for you. Your provider might consider changing your regimen if there are other options available to you that don't raise blood sugar levels. If you and your provider choose to continue Evotaz (atazanavir / cobicistat), you might need to check your blood sugar more often. Tell your provider if your blood sugar goes up. Your provider might recommend making dietary and lifestyle changes, adding medications to your diabetes treatment, or switching your HIV medications.
            How long does it take for Evotaz (atazanavir / cobicistat) to leave your system?
            It can take about a day and a half for most of Evotaz (atazanavir / cobicistat) to leave your system after your dose. This calculation is based on the medication's half-life (about 7 hours), which is the time it takes half of the original dose to leave your body. As soon as you take your dose, your body begins to break it down; medications usually clear from your body after about 5 half-lives. Keep in mind that the medication's half-life can differ if you have liver problems or if you take Evotaz (atazanavir / cobicistat) with interacting medications. These factors can affect how long it takes the medication to leave your system.
            Can you take Truvada and Evotaz (atazanavir / cobicistat) together?
            Yes, you can take Truvada with Evotaz (atazanavir / cobicistat) if your provider says so. HIV treatment regimens are usually made up of two or three HIV medications. These medications should be from at least two different HIV drug classes. Truvada and Evotaz (atazanavir / cobicistat) belong to different antiretroviral drug classes: Truvada is a combination of two nucleoside reverse transcriptase inhibitors (NRTIs), whereas Evotaz (atazanavir / cobicistat) is a "boosted" protease inhibitor. Ask your provider whether taking Truvada and Evotaz (atazanavir / cobicistat) is right for you.
            Can Evotaz (atazanavir / cobicistat) be taken by itself for HIV?
            No, even though Evotaz (atazanavir / cobicistat) is a combination of two medications, it's not a full regimen. Atazanavir helps prevent HIV from spreading, and cobicistat is used as a "booster" to help keep atazanavir levels high in the body. A full HIV regimen requires two or three medications from at least two different drug classes that directly fight against HIV. For this reason, you must take Evotaz (atazanavir / cobicistat) with another HIV medication. Your provider will make sure you have a complete regimen to treat your HIV.
            Can I take Evotaz (atazanavir / cobicistat) during pregnancy?
            No, Evotaz (atazanavir / cobicistat) shouldn't be used during pregnancy because pregnancy can lower the amount of medication in your body and it won't control your HIV. To prevent pregnancy while you're taking Evotaz (atazanavir / cobicistat), consider using back-up or nonhormonal birth control; certain hormonal birth control methods might not work when you're taking this HIV medication. Make sure to talk with your provider if you're pregnant or think you might be pregnant. Your provider can discuss switching you to a different HIV regimen that's safe during pregnancy.
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            What are the risks and warnings for Evotaz (atazanavir / cobicistat)?

            Evotaz (atazanavir / cobicistat) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Heart rhythm problems

            • Risk factors: History of heartbeat problems | Taking medications that can affect heart rhythm

              Evotaz (atazanavir / cobicistat) can affect your heart rhythm, which can sometimes be serious. Your risk might be higher if you have heart rhythm problems (e.g., heart block) or if you take other medications that cause changes in heart rhythm. Make sure your HIV provider and cardiologist know about the medical conditions you have and the medications you're taking. Your cardiologist might choose to monitor your heartbeat more often if you're at risk for changes in heart rhythm. Get medical attention right away if you feel your chest pounding, have trouble breathing, have chest pain, or feel faint or lightheaded while you're taking Evotaz (atazanavir / cobicistat).

              risk-warning

              Rash and other severe skin reactions

              Tell your provider about any new rashes that you have after you start Evotaz (atazanavir / cobicistat). Some people who took this medication had rash and other severe skin reactions. In studies, mild-to-moderate rashes happened within the first 7 weeks of treatment and often went away after a week or so. But stop the medication and get medical attention right away if you get a severe rash, high fever, muscle or joint pain, mouth sores, blisters, or peeling skin. These can be signs of a severe skin reaction.

              risk-warning

              Kidney problems

              • Risk factors: History of kidney damage | Also taking tenofovir disoproxil fumarate | Taking other medications that can cause kidney problems

                Evotaz (atazanavir / cobicistat) can cause changes to your blood test results that tell your provider about your kidney health. In some cases, these changes can suggest kidney damage. In addition, some people who took Evotaz (atazanavir / cobicistat) reported developing kidney problems.

                The risk for kidney damage might be higher for people with a history of kidney problems and for people taking other medications that can harm the kidneys, including tenofovir disoproxil fumarate (Viread) and NSAIDs like ibuprofen (Advil). Tell your provider about your medical conditions and the medications you take (including over-the-counter pain or cold medications). Also, get routine blood work done so your provider can check your kidney function.

                risk-warning

                Kidney stones or gallstones

                Some people taking Evotaz (atazanavir / cobicistat) have kidney stones or gallstones. Talk to your provider if you notice any signs of kidney stones or gallstones, such as unusual pain in your stomach or sides with nausea or vomiting, difficulty urinating, fever, or blood in your urine.

                risk-warning

                Liver problems

                • Risk factors: History of liver problems | Hepatitis B or C infection

                  Some people have had elevated liver enzyme levels after they start Evotaz (atazanavir / cobicistat). These changes might suggest liver damage. Some people with liver conditions, like hepatitis B or hepatitis C infection, are at risk for worsening liver problems. Make sure your healthcare providers know about the medical conditions you have. Your provider might order blood tests to check your liver before you start Evotaz (atazanavir / cobicistat) and periodically during treatment.

                  risk-warning

                  High bilirubin levels

                  Evotaz (atazanavir / cobicistat) can raise your blood levels of bilirubin, which can lead to jaundice (yellowing of the skin or the white part of your eyes). Let your provider know if you develop jaundice. Discuss with your provider whether you can switch to a different HIV medication if you're concerned about your skin or eye color. This yellowing will go away once Evotaz (atazanavir / cobicistat) is stopped, but don't stop the medication until your provider tells you to so your HIV treatment isn't interrupted.

                  risk-warning

                  Interactions with other medications (including certain HIV ARVs)

                  Evotaz (atazanavir / cobicistat) interacts with a lot of medications. Many times, Evotaz (atazanavir / cobicistat) causes the levels of other medications to build up in your body, which can lead to serious or deadly side effects. Other times, medications can lower Evotaz (atazanavir / cobicistat) levels in the body and interfere with how the HIV medication works.

                  It isn't recommended to use Evotaz (atazanavir / cobicistat) with other HIV medications that need boosting, like other protease inhibitors or medications containing elvitegravir (e.g., Genvoya, Stribild). Doing so might make the medications work less well and raise the risk for drug resistance. It also isn't recommended to use Evotaz (atazanavir / cobicistat) with other medications containing ritonavir (Norvir) because cobicistat and ritonavir work similarly.

                  Because of the risk for drug interactions, it's important to talk to your healthcare providers and pharmacists before you start or stop any medications. Your providers can check that your medications are safe for you.

                  risk-warning

                  Overactive immune system

                  Taking combination ARV therapy can cause changes to your immune system called immune reconstitution syndrome. This condition happens when your immune system becomes overly active after you start combination therapy. Your immune system begins to fight off different infections that it was too weak to fight off before you started treatment. In rare cases, your immune response might improve so much with treatment that it starts to attack normal cells in your body. You can develop these autoimmune conditions at any time (during the first few weeks of treatment or many months later). Tell your provider right away if you have any new symptoms, such as fever, pain, trouble breathing, hair loss, bulging eyes, sweating, or other sudden changes to your health, after you start Evotaz (atazanavir / cobicistat).

                  risk-warning

                  High blood sugar

                  Some people taking protease inhibitors like Evotaz (atazanavir / cobicistat) had high blood sugar levels. Sometimes, this led to diabetes or worsened diabetes. If this happens, your provider might need to adjust your diabetes medications to make sure your blood sugar is under control. Tell your provider before you start Evotaz (atazanavir / cobicistat) if you have a history of diabetes. Your provider might recommend that you check your blood sugar at home to make sure this medication is safe for you.

                  risk-warning

                  Changes in body fat

                  Some people taking HIV medications, such as Evotaz (atazanavir / cobicistat), have noticed changes in body fat. These changes might look like fat buildup in the upper back, breast, or stomach area. Other people have also lost fat from the legs, arm, and face. It's not clear whether Evotaz (atazanavir / cobicistat) causes these changes to body fat, why this happens, and whether it will affect your health in the future. Tell your provider if you notice these changes while you're taking Evotaz (atazanavir / cobicistat).

                  risk-warning

                  Risk of bleeding in people with hemophilia

                  Some people who have a genetic bleeding condition called hemophilia have had more bleeding after starting protease inhibitors like Evotaz (atazanavir / cobicistat). Some people might need treatment with blood products like factor VIII. In most cases, treatment with Evotaz (atazanavir / cobicistat) continued or was restarted after the bleeding stopped. It's not clear whether the medication is related to more bleeding. Tell your provider if you have hemophilia before you start Evotaz (atazanavir / cobicistat).

                  dosage

                  Evotaz (atazanavir / cobicistat) dosage forms

                  Typical dosing for Evotaz (atazanavir / cobicistat)

                  Each tablet contains 300 mg of atazanavir and 150 mg of cobicistat.

                  The typical dose is 1 tablet by mouth once a day with food.

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                  How much does Evotaz (atazanavir / cobicistat) cost?

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                  contraindications-icon

                  Evotaz (atazanavir / cobicistat) contraindications

                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Evotaz (atazanavir / cobicistat) will not be safe for you to take.
                  alternatives

                  What are alternatives to Evotaz (atazanavir / cobicistat)?

                  There are a number of medications that your doctor can prescribe in place of Evotaz (atazanavir / cobicistat). Compare a few possible alternatives below.
                  Evotaz (atazanavir / cobicistat)
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                  • Treatment of HIV

                  $1579.91 Lowest GoodRx priceView Prices
                  Used for:
                  • Treatment of HIV infection in adults and children weighing at least 88 pounds

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                  Evotaz (atazanavir / cobicistat) images

                  Pink Oval 3641 - EVOTAZ 300mg-150mg Tablet
                  This medicine is Pink, Oval Tablet Imprinted With "3641".Pink Oval 3641 - EVOTAZ 300mg-150mg Tablet

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                  References

                  Best studies we found

                  Bristol-Myers Squibb Company. (n.d.). How you should take Evotaz.

                  Bristol-Myers Squibb Company. (n.d.). Meds to avoid.

                  Bristol-Myers Squibb Company. (n.d.). Possible side effects.

                  View All References (12)

                  California State Board of Pharmacy. (2015). Splitting pills: Understanding the benefits and risks.

                  Clinical Info HIV.gov. (n.d.). Boosting.

                  Clinical Info HIV.gov. (n.d.). Immune reconstitution inflammatory syndrome (IRIS).

                  Clinical Info HIV.gov. (n.d.). Nucleoside reverse transcriptase inhibitor (NRTI).

                  Clinical Info HIV.gov. (n.d.). Protease inhibitor (PI).

                  Clinical Info HIV.gov. (2022). What to start.

                  E.R. Squibb & Sons, L.L.C. (2023). Evotaz- atazanavir and cobicistat tablet [package insert]. DailyMed.

                  Hallare, J., et al. (2023). Half life. StatPearls.

                  HIVinfo.NIH.gov. (2021). Drug resistance.

                  MedlinePlus. (2022). Bilirubin blood test.

                  SafeMedication. (2022). What if I miss a dose of my medication?

                  Thapa, S., et al. (2023). Immune reconstitution inflammatory syndrome. StatPearls.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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