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Evotaz vs. Triumeq

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Evotaz (atazanavir/cobicistat) and Triumeq (abacavir/dolutegravir/lamivudine) are both medications used to treat HIV, but they have some key differences. Evotaz is a combination of two drugs: atazanavir, a protease inhibitor, and cobicistat, a booster that helps maintain higher levels of atazanavir in your blood. It must be taken with other HIV medications and always with food. On the other hand, Triumeq is a single-tablet regimen that combines three drugs: abacavir and lamivudine, both nucleoside reverse transcriptase inhibitors (NRTIs), and dolutegravir, an integrase inhibitor. Triumeq can be taken with or without food and is a complete treatment on its own. Before starting Triumeq, you need a genetic test to check for a specific trait that could cause a severe allergic reaction, which is not required for Evotaz. Additionally, Triumeq is available in a dissolvable tablet form for children, while Evotaz is only available as a standard tablet. Both medications have their own sets of side effects and interactions, so it's important to discuss with your healthcare provider which option is best for you.

Evotaz

(atazanavir / cobicistat)

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Triumeq

 

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Summary for Evotaz

Prescription only

Evotaz (atazanavir / cobicistat) is a combination medication that's taken as part of an antiretroviral (ARV) regimen to treat HIV (human immunodeficiency virus). It's approved for people with HIV who weigh at least 77 pounds. Evotaz (atazanavir / cobicistat) is a tablet that's taken once a day with food. It must be taken along with other HIV ARV medications. Evotaz (atazanavir / cobicistat) can cause side effects, including rash and jaundice (yellowing of the skin or eyes).

Indications for Evotaz

  • Treatment of HIV

Pros and Cons for Evotaz

Pros

  • Taken once a day
  • Combination tablet, so there are fewer pills to take
  • Same dose for adults and children who weigh at least 77 pounds
  • Can take if you have a sulfa allergy

Cons

Common Side Effects for Evotaz

  • Jaundice (yellowing of the skin or eyes; up to 6%)
  • Rash (5%)

Warnings for Evotaz

  • Heart rhythm problems
  • Rash and other severe skin reactions
  • Kidney problems
  • Kidney stones or gallstones
  • Liver problems
  • High bilirubin levels
  • Interactions with other medications (including certain HIV ARVs)
  • Overactive immune system
  • High blood sugar
  • Changes in body fat
  • Risk of bleeding in people with hemophilia

Summary for Triumeq

Prescription only

Triumeq is a single-tablet regimen used to treat human immunodeficiency virus (HIV) infections. It contains 3 antiretrovirals (ARVs): abacavir, dolutegravir, and lamivudine. Triumeq is available as either a tablet or a dissolvable tablet for oral suspension (Triumeq PD), but the two are not the same. Before starting treatment, your provider will require you to get a genetic test to see if you're at risk for developing a serious allergic reaction to this medication.

Indications for Triumeq

  • Treatment of HIV infection (in people who weigh at least 13 pounds)

Pros and Cons for Triumeq

Pros

  • Only taken once a day for complete HIV treatment
  • Combines three medications into one pill for convenience
  • Can be taken with or without food
  • Available for adults and children at or over 22 lbs

Cons

  • Dose can't be adjusted so it's not recommended for people with kidney or liver problems
  • Not safe to use in severe liver problems
  • Requires a genetic test before starting
  • Interacts with a lot of medications such as St. John’s wort and oxcarbazepine (Trileptal)

Common Side Effects for Triumeq

  • Higher lipase levels (suggesting irritated pancreas) (up to 11%)
  • Higher blood sugar levels (up to 9%)
  • Higher creatine kinase levels in the blood (suggesting muscle damage) (up to 7%)
  • Higher fat levels in the blood (up to 6%)
  • Higher white blood cell count (up to 4%)
  • Abnormal liver labs (up to 3%)
  • Trouble sleeping (3%)
  • Headache (2%)
  • Feeling tired (2%)

Please note: The side effects listed above are from clinical trials with Tivicay (dolutegravir) and Epzicom (abacavir / lamivudine), which are all active ingredients in Triumeq and Triumeq PD

Warnings for Triumeq

  • Serious allergic reaction
  • Worsening of hepatitis B virus (HBV) infection
  • Liver problems
  • Overactive immune system
  • Interaction with other medications

Prices with our coupons for Evotaz vs. Triumeq

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Evotaz30 tablets / 300mg/150mg
$1,547.50-
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Triumeq30 tablets / 600mg/50mg/300mg
$3,906.39$5,011.89
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