Key takeaways
Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) and Efavirenz (Sustiva) are both used to treat HIV infections, but they have some key differences. Genvoya is a combination of four medications, including two NRTIs, an INSTI, and a booster, and is taken once daily with food. Efavirenz (Sustiva), on the other hand, is a single NNRTI that is taken once daily at bedtime on an empty stomach. Genvoya is not available as a generic, while Efavirenz (Sustiva) is available in both brand-name and generic forms. Genvoya is not recommended for use during pregnancy, and neither is Efavirenz (Sustiva), which can cause birth defects if taken during the first trimester. Common side effects of Genvoya include nausea and diarrhea, whereas Efavirenz (Sustiva) can cause dizziness, trouble sleeping, and rash. Additionally, Efavirenz (Sustiva) has more potential for serious side effects, such as nerve issues and mood problems, compared to Genvoya.
