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Compare Tivicay vs. Genvoya

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tivicay (dolutegravir) and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) are both medications used to treat HIV, but they have some key differences. Tivicay is an integrase inhibitor that blocks the enzyme HIV uses to insert its genetic material into your cells. It comes in two formulations: a tablet and a tablet for suspension, and it does not have a generic version. Genvoya, on the other hand, is a combination of four medications: two NRTIs (emtricitabine and tenofovir alafenamide), an integrase inhibitor (elvitegravir), and a booster (cobicistat). Genvoya is taken as a single tablet once daily with food and also does not have a generic version. Tivicay must be taken with other HIV antiretrovirals to make up a complete treatment regimen. While Tivicay can be used for post-exposure prophylaxis (PEP), Genvoya is not approved for PEP or pre-exposure prophylaxis (PrEP). Additionally, Tivicay can be used in children as young as 4 weeks old, whereas Genvoya is only for adults and children who weigh at least 55 pounds. Both medications have potential side effects and interactions with other medications, but Genvoya has specific warnings about worsening hepatitis B if stopped suddenly and must be taken with food.

  • Tivicay (dolutegravir)
    Genvoya
  • Tivicay (dolutegravir)
    Genvoya

  • Summary of Tivicay vs. Genvoya

    Summary for HIV ARV
    Prescription only

    Tivicay (dolutegravir) is a medication that's used as part of an antiretroviral (ARV) regimen for treating human immunodeficiency virus (HIV) infections. Some side effects can include trouble sleeping, tiredness, and headache, but they aren't very common with this medication. Tivicay (dolutegravir) comes as two different formulations: a tablet that you swallow whole and a tablet that you mix in water to make into a liquid solution. Tivicay (dolutegravir) is only available as a brand-name medication; there's no generic at this time.

    Summary for HIV ARV combo
    Prescription only

    Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide) is a combination antiretroviral therapy (ART) that treats human immunodeficiency virus (HIV) infections in adults and children. It's made up of two nucleoside reverse transcriptase inhibitors (NRTIs), emtricitabine and tenofovir alafenamide; an integrase strand transfer inhibitor (INSTI) called elvitegravir; and a "booster" medication known as cobicistat. Genvoya is taken by mouth, typically once daily. Some common side effects of this medication include nausea and diarrhea. It's not available as a generic medication.

  • Indications of Tivicay vs. Genvoya

    Indications for
    •Treatment of HIV infection in people aged 4 weeks and older
    Indications for
    •Treatment of HIV infection

  • Pros and Cons of Tivicay vs. Genvoya

    Pros and Const for HIV ARV
    Pros
    •Can take with or without food
    •Available for adults and children at least 4 weeks old and weighing at least 7 pounds
    •Has an oral tablet formulation that can be dissolved in water and taken as a solution (Tivicay PD), so it's convenient if you have trouble swallowing pills
    Cons
    •Interacts with a lot of medications, such as some other HIV medications, anti-seizure medications (e.g., oxcarbazepine (Trileptal)), and antacids
    •Can't take with dofetilide (Tikosyn) because of risk of serious side events
    •Not recommended for use if you have severe liver problems
    Pros and Const for HIV ARV combo
    Pros
    •Is a complete regimen for HIV treatment
    •Only taken once a day
    •Taken by mouth
    Cons
    •Needs to be taken with food
    •Can’t take while pregnant
    •Can worsen hepatitis B if you stop taking the medication all of a sudden

  • Common Side Effects of Tivicay vs. Genvoya

    Common Side Effects for

    The following side effects were reported in adults taking this medication with other HIV ARVs. Side effects might differ in children.

    •Higher lipase levels (up to 11%)
    •Higher blood sugar levels (up to 9%)
    •Higher creatine kinase levels in the blood (up to 7%)
    •Abnormal liver labs (up to 5%)
    •Trouble sleeping (up to 3%)
    •Headache (up to 2%)
    •Feeling tired (up to 2%)
    Common Side Effects for
    •Nausea (11%)
    •Diarrhea (7%)
    •Headache (6%)
    •Feeling tired (5%)

  • Warnings of Tivicay vs. Genvoya

    Common Side Effects for
    •Allergic reaction
    •Liver problems
    •Overactive immune system
    •Interactions with other medications
    •Harm to unborn baby
    Common Side Effects for
    •Worsening of hepatitis B infection
    •Kidney problems
    •Liver problems and lactic acidosis
    •Overactive immune system
    •Interaction with other medications

  • Prices with our coupons for Tivicay vs. Genvoya

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