Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Prezcobix (darunavir/cobicistat) and Triumeq (abacavir/dolutegravir/lamivudine) are both medications used to treat HIV, but they have some key differences. Prezcobix combines two drugs: darunavir, a protease inhibitor, and cobicistat, a booster that helps darunavir work better. It's taken once daily with food and is suitable for adults and children weighing at least 88 pounds. Triumeq, on the other hand, is a single-tablet regimen that includes three drugs: abacavir and lamivudine, both nucleoside reverse transcriptase inhibitors (NRTIs), and dolutegravir, an integrase inhibitor. Triumeq can be taken with or without food and is available for adults and children weighing at least 22 pounds. Before starting Triumeq, you need a genetic test to check for a specific trait that could cause a severe allergic reaction, which is not required for Prezcobix. Additionally, Triumeq is not recommended for people with severe liver problems, while Prezcobix must be used carefully in people with sulfa allergies and is not recommended during pregnancy. Both medications interact with many other drugs, so it's important to discuss all your medications with your healthcare provider.
Prezcobix (darunavir / cobicistat)
Triumeq
Prezcobix (darunavir / cobicistat)
Triumeq
Summary of Prezcobix vs. Triumeq
Summary for HIV ARV
Prescription only
Prezcobix (darunavir / cobicistat), also known as DRV/COBI, is an antiretroviral (ARV) medication that treats HIV (human immunodeficiency virus) infections in people who weigh at least 88 pounds. It's typically taken with other HIV ARVs to make up a complete treatment regimen. Prezcobix (darunavir / cobicistat) is an oral tablet that's taken once daily. It's important to take the medication every day to prevent HIV drug resistance (when HIV medications no longer work). A side effect of Prezcobix (darunavir / cobicistat) is a skin rash that appears within the first month of treatment, but it typically goes away on its own.
Summary for HIV ARV
Prescription only
Triumeq is a single-tablet regimen used to treat human immunodeficiency virus (HIV) infections. It contains 3 antiretrovirals (ARVs): abacavir, dolutegravir, and lamivudine. Triumeq is available as either a tablet or a dissolvable tablet for oral suspension (Triumeq PD), but the two are not the same. Before starting treatment, your provider will require you to get a genetic test to see if you're at risk for developing a serious allergic reaction to this medication.
Indications of Prezcobix vs. Triumeq
Indications for
•Treatment of HIV infection in adults and children weighing at least 88 pounds
Indications for
•Treatment of HIV infection (in people who weigh at least 22 pounds)
Pros and Cons of Prezcobix vs. Triumeq
Pros and Const for HIV ARV
Pros
•Taken once a day by mouth
•Combines two medications into one pill for convenience
•Safe to use in adults and children weighing at least 88 pounds