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Compare Prezista vs. Prezcobix

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezista (darunavir) and Prezcobix (darunavir/cobicistat) are both medications used to treat HIV infections, but they have some key differences. Prezista is taken with a booster like ritonavir (Norvir) to help it work better, while Prezcobix already includes a booster, cobicistat, in the same pill. This makes Prezcobix more convenient since it combines two medications into one tablet. Prezista can be used in children as young as 3 years old, whereas Prezcobix is only for people weighing at least 88 pounds. Prezista is available as both a tablet and an oral suspension, which can be helpful if you have trouble swallowing pills, but Prezcobix is only available as a tablet. Both medications need to be taken with food and can cause similar side effects like rash and liver problems. However, Prezcobix is not recommended during pregnancy, while Prezista can be used safely during pregnancy.

  • Prezista (darunavir)
    Prezcobix (darunavir / cobicistat)
  • Prezista (darunavir)
    Prezcobix (darunavir / cobicistat)

  • Summary of Prezista vs. Prezcobix

    Summary for HIV ARV
    Prescription only

    Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.

    Summary for HIV ARV
    Prescription only

    Prezcobix (darunavir / cobicistat), also known as DRV/COBI, is an antiretroviral (ARV) medication that treats HIV (human immunodeficiency virus) infections in people who weigh at least 88 pounds. It's typically taken with other HIV ARVs to make up a complete treatment regimen. Prezcobix (darunavir / cobicistat) is an oral tablet that's taken once daily. It's important to take the medication every day to prevent HIV drug resistance (when HIV medications no longer work). A side effect of Prezcobix (darunavir / cobicistat) is a skin rash that appears within the first month of treatment, but it typically goes away on its own.

  • Indications of Prezista vs. Prezcobix

    Indications for
    •Treatment of HIV infection in people aged 3 years and older
    Indications for
    •Treatment of HIV infection in adults and children weighing at least 88 pounds

  • Pros and Cons of Prezista vs. Prezcobix

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Available as an oral suspension, so it's convenient if you have trouble swallowing pills
    •Safe to take during pregnancy
    Cons
    •Requires regular blood work and lab tests
    •Interacts with many medications
    •Must be used carefully in people with sulfa allergies
    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Combines two medications into one pill for convenience
    •Safe to use in adults and children weighing at least 88 pounds
    Cons
    •Interacts with many medications, such as certain statins and blood thinners
    •Must be used carefully in people with sulfa allergies
    •Not recommended during pregnancy (being pregnant can cause the medication to work less well)

  • Common Side Effects of Prezista vs. Prezcobix

    Common Side Effects for
    •Diarrhea (9-14%)
    •Rash (6-7%)
    •Nausea (4-7%)
    •Headache (3-7%)
    •Stomach pain (6%)
    •Vomiting (2-5%)

    Side effects above were reported in adults taking this medication with ritonavir (Norvir). Side effects might differ in children.

    Common Side Effects for

    Side effects below were reported in at least 5% of adults taking Prezista (darunavir) with ritonavir (Norvir) during clinical studies.

    •Diarrhea
    •Nausea
    •Stomach pain
    •Vomiting
    •Headache
    •Rash

    Side effects below were reported in at least 5% of adults taking Tybost (cobicistat) with other HIV medications in clinical studies.

    •Jaundice
    •Rash

  • Warnings of Prezista vs. Prezcobix

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes in body fat
    •Overactive immune system
    •Bleeding
    •Interactions with other medications
    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes to blood test results for kidney function
    •Kidney problems when used with tenofovir disoproxil fumarate (TDF)
    •High blood sugar
    •Changes in body fat
    •Overactive immune system
    •Risk of bleeding in people with hemophilia
    •Interactions with other medications

  • Prices with our coupons for Prezista vs. Prezcobix

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