Key takeaways
Fosamprenavir (Lexiva) and tipranavir (Aptivus) are both antiretroviral (ARV) medications used to treat HIV in combination with other antiretrovirals. They belong to the same class of medications called protease inhibitors, which work by blocking a protein that helps the HIV virus infect healthy cells. However, there are several differences between the two. Fosamprenavir (Lexiva) is available as an oral tablet or suspension and is typically taken twice daily, often with a booster like ritonavir (Norvir). Tipranavir (Aptivus) is also taken with ritonavir but requires multiple capsules daily. Fosamprenavir can be used in children as young as 4 weeks, while tipranavir is approved for children aged 2 years and older. Both medications can cause high cholesterol and blood sugar levels, but fosamprenavir is more likely to cause serious side effects like severe skin reactions and liver problems. Tipranavir has a risk of bleeding in the brain, which is rare. Both medications interact with many other drugs, so it's important to tell your healthcare provider about all the medications you are taking.
