Key takeaways
Prezista (darunavir) and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) are both used to treat HIV infections, but they have some key differences. Prezista is a protease inhibitor that needs to be taken with a booster like ritonavir (Norvir) and food, while Genvoya is a combination of four medications, including two NRTIs, an INSTI, and a booster, and also needs to be taken with food. Prezista is available as an oral tablet or suspension, making it easier for those who have trouble swallowing pills, whereas Genvoya is only available as a tablet. Prezista can be used during pregnancy, but Genvoya cannot. Additionally, Prezista requires regular blood tests to monitor liver health, especially in those with hepatitis B or C, while Genvoya can worsen hepatitis B if stopped suddenly. Both medications have common side effects like nausea and diarrhea, but Prezista also has a risk of severe skin reactions and changes in body fat distribution. Genvoya, on the other hand, can cause kidney problems and lactic acidosis. Lastly, Prezista has a generic form, while Genvoya does not.
