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Compare Lexiva vs. Crixivan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Fosamprenavir (Lexiva) and indinavir (Crixivan) are both medications used to treat HIV infections and belong to the protease inhibitor class of antiretroviral (ARV) medications. However, there are several differences between them. Fosamprenavir (Lexiva) is still available as an oral tablet or suspension, while indinavir (Crixivan) has been discontinued in the U.S. due to business reasons and the availability of newer treatments. Fosamprenavir (Lexiva) is typically taken twice daily and often requires a "booster" like ritonavir to enhance its effectiveness, whereas indinavir (Crixivan) was taken without such a booster. Fosamprenavir (Lexiva) can cause side effects like rash, diarrhea, and nausea, and it interacts with many other medications, including birth control pills and PDE5 inhibitors like sildenafil. Indinavir (Crixivan) was known for its side effects and interactions, which contributed to its decline in use. While fosamprenavir (Lexiva) is still prescribed, it is not a first-choice option due to its side effects and interactions, similar to why indinavir (Crixivan) fell out of favor before being discontinued.

  • Fosamprenavir (Lexiva)
    Crixivan (indinavir)
  • Fosamprenavir (Lexiva)
    Crixivan (indinavir)

  • Summary of Lexiva vs. Crixivan

    Summary for HIV ARV
    Prescription only

    Fosamprenavir (Lexiva) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's typically taken twice daily, usually in combination with a "booster," like ritonavir (Norvir), to help fosamprenavir (Lexiva) work better against the virus. Fosamprenavir (Lexiva) isn't a first-choice option for HIV anymore because it can cause serious side effects (e.g., rash, diarrhea, and nausea) and can interact with many other medications.

    Summary for HIV ARV

    Crixivan (indinavir) was one of the first HIV antiretroviral (ARV) medications approved by the FDA. Due to side effects and medication interactions, it has not been a first choice treatment option for many years and has been discontinued in the U.S.

  • Indications of Lexiva vs. Crixivan

    Indications for
    •Treatment of HIV infection
    Indications for

  • Pros and Cons of Lexiva vs. Crixivan

    Pros and Const for HIV ARV
    Pros
    •Available in a liquid form for people who have difficulty swallowing pills
    •Can be used in children age 4 weeks and older
    •Tablets can be taken with or without food
    Cons
    •Interacts with many medications
    •Requires regular blood work and lab tests to make sure your liver is healthy
    •Likely to cause high blood sugar and cholesterol levels
    Pros and Const for HIV ARV
    Pros
    Cons

  • Common Side Effects of Lexiva vs. Crixivan

    Common Side Effects for
    •Diarrhea (5-13%)
    •Higher levels of fats in the body (up to 11%)
    •Higher liver labs (6-8%)
    •Rash (3-8%)
    •Nausea (3-7%)

    Please note: The side effects above include those reported by people who also took ritonavir (Norvir) with fosamprenavir (Lexiva) during clinical trials.

    Common Side Effects for

  • Warnings of Lexiva vs. Crixivan

    Common Side Effects for
    •Interactions with other medications
    •Severe skin and allergic reactions
    •Liver problems
    •High blood sugar
    •Overactive immune system
    •Changes in body fat
    •Higher cholesterol levels
    •Risk of bleeding
    •Risk of kidney stone
    Common Side Effects for

  • Prices with our coupons for Lexiva vs. Crixivan

    Learn more about Fosamprenavir
    Learn more about Crixivan

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