Key takeaways
Fosamprenavir (Lexiva) and indinavir (Crixivan) are both medications used to treat HIV infections and belong to the protease inhibitor class of antiretroviral (ARV) medications. However, there are several differences between them. Fosamprenavir (Lexiva) is still available as an oral tablet or suspension, while indinavir (Crixivan) has been discontinued in the U.S. due to business reasons and the availability of newer treatments. Fosamprenavir (Lexiva) is typically taken twice daily and often requires a "booster" like ritonavir to enhance its effectiveness, whereas indinavir (Crixivan) was taken without such a booster. Fosamprenavir (Lexiva) can cause side effects like rash, diarrhea, and nausea, and it interacts with many other medications, including birth control pills and PDE5 inhibitors like sildenafil. Indinavir (Crixivan) was known for its side effects and interactions, which contributed to its decline in use. While fosamprenavir (Lexiva) is still prescribed, it is not a first-choice option due to its side effects and interactions, similar to why indinavir (Crixivan) fell out of favor before being discontinued.
