Head-to-head comparisons of medication uses, side effects, warnings, and more.
Fosamprenavir (Lexiva)
Crixivan (indinavir)
Fosamprenavir (Lexiva)
Crixivan (indinavir)
Summary of Lexiva vs. Crixivan
Summary for HIV ARV
Prescription only
Fosamprenavir (Lexiva) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's typically taken twice daily, usually in combination with a "booster," like ritonavir (Norvir), to help fosamprenavir (Lexiva) work better against the virus. Fosamprenavir (Lexiva) isn't a first-choice option for HIV anymore because it can cause serious side effects (e.g., rash, diarrhea, and nausea) and can interact with many other medications.
Summary for HIV ARV
Crixivan (indinavir) was one of the first HIV antiretroviral (ARV) medications approved by the FDA. Due to side effects and medication interactions, it has not been a first choice treatment option for many years and has been discontinued in the U.S.
Indications of Lexiva vs. Crixivan
Indications for
•Treatment of HIV infection
Indications for
Pros and Cons of Lexiva vs. Crixivan
Pros and Const for HIV ARV
Pros
•Available in a liquid form for people who have difficulty swallowing pills
•Can be used in children age 4 weeks and older
•Tablets can be taken with or without food
Cons
•Interacts with many medications
•Requires regular blood work and lab tests to make sure your liver is healthy
•Likely to cause high blood sugar and cholesterol levels
Pros and Const for HIV ARV
Pros
Cons
Common Side Effects of Lexiva vs. Crixivan
Common Side Effects for
•Diarrhea (5-13%)
•Higher levels of fats in the body (up to 11%)
•Higher liver labs (6-8%)
•Rash (3-8%)
•Nausea (3-7%)
Please note: The side effects above include those reported by people who also took ritonavir (Norvir) with fosamprenavir (Lexiva) during clinical trials.