Key takeaways
Invirase (saquinavir) and Aptivus (tipranavir) are both protease inhibitors used to treat HIV. However, they have several differences. Invirase is specifically approved for use in people over 16 years old, while Aptivus can be used in children as young as 2 years old. Invirase comes as a tablet, whereas Aptivus is available as capsules and an oral solution. Both medications require the use of ritonavir (Norvir) as a booster, but Invirase must be taken with food, while Aptivus can be taken with or without food. Both medications can cause nausea, diarrhea, and fatigue. Invirase has a risk of causing changes to heart rhythm, while Aptivus has a rare risk of bleeding in the brain. Both medications can raise cholesterol and blood sugar levels. Aptivus is not recommended for people with sulfa allergies.
