Key takeaways
Invirase (saquinavir) and Crixivan (indinavir) are both medications used to treat HIV and belong to the protease inhibitor class. However, there are several differences between them. Invirase (saquinavir) is still available and is taken orally as part of an antiretroviral regimen, requiring co-administration with ritonavir (Norvir) to enhance its effectiveness. It is prescribed for adults and children over 16 years old. Common side effects include nausea, diarrhea, and vomiting, and it can interact with many other medications, potentially causing serious issues like heart rhythm problems. On the other hand, Crixivan (indinavir) has been discontinued in the U.S. due to business reasons and is no longer available in brand or generic forms. While both medications are protease inhibitors, Invirase (saquinavir) remains in use, whereas Crixivan (indinavir) is not an option for treatment anymore.
