Key takeaways
Prezista (darunavir) and Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir) are both medications used to treat HIV. However, they belong to different medication classes. Prezista is a protease inhibitor, while Stribild is a combination of an integrase inhibitor and two nucleoside reverse transcriptase inhibitors (NRTIs), along with a booster. Prezista is typically taken with ritonavir (Norvir) to enhance its effectiveness, whereas Stribild is a single-tablet regimen that includes its own booster, cobicistat. Prezista is available as a tablet or oral suspension, while Striblid is only available as a tablet. Both medications are taken once daily with food, but Stribild is not recommended for people with kidney or liver problems. Prezista can be used during pregnancy, but Stribild is not recommended during pregnancy. Common side effects of Prezista include diarrhea and rash, while Stribild may cause nausea, diarrhea, and abnormal dreams. Both medications interact with many other drugs, so it's important to discuss all medications you're taking with your prescriber and pharmacist. Prezista contains a sulfa component, so talk to your prescriber if you have a sulfa allergy.
