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Compare Prezista vs. Stribild

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezista (darunavir) and Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir) are both medications used to treat HIV. However, they belong to different medication classes. Prezista is a protease inhibitor, while Stribild is a combination of an integrase inhibitor and two nucleoside reverse transcriptase inhibitors (NRTIs), along with a booster. Prezista is typically taken with ritonavir (Norvir) to enhance its effectiveness, whereas Stribild is a single-tablet regimen that includes its own booster, cobicistat. Prezista is available as a tablet or oral suspension, while Striblid is only available as a tablet. Both medications are taken once daily with food, but Stribild is not recommended for people with kidney or liver problems. Prezista can be used during pregnancy, but Stribild is not recommended during pregnancy. Common side effects of Prezista include diarrhea and rash, while Stribild may cause nausea, diarrhea, and abnormal dreams. Both medications interact with many other drugs, so it's important to discuss all medications you're taking with your prescriber and pharmacist. Prezista contains a sulfa component, so talk to your prescriber if you have a sulfa allergy.

  • Prezista (darunavir)
    Stribild
  • Prezista (darunavir)
    Stribild

  • Summary of Prezista vs. Stribild

    Summary for HIV ARV
    Prescription only

    Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.

    Summary for HIV ARV Combo
    Prescription only

    Stribild is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), elvitegravir (Vitekta), emtricitabine (Emtriva), and tenofovir DF (Viread), and one booster medication, cobicistat (Tybost).

  • Indications of Prezista vs. Stribild

    Indications for
    •Treatment of HIV infection in people aged 3 years and older
    Indications for
    •HIV treatment

  • Pros and Cons of Prezista vs. Stribild

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Available as an oral suspension, so it's convenient if you have trouble swallowing pills
    •Safe to take during pregnancy
    Cons
    •Requires regular blood work and lab tests
    •Interacts with many medications
    •Must be used carefully in people with sulfa allergies
    Pros and Const for HIV ARV Combo
    Pros
    •1 tablet once a day is a full HIV regimen
    •Contains tenofovir, which is also a first-choice treatment option for hepatitis B
    •One of the few single-tablet-regimens that contains an integrase inhibitor (a preferred HIV ARV subclass)
    •In clinical trials, caused less abnormal dreams than Atripla
    •Gilead copay card available for people with commercial health plans (not for use with Medicaid and Medicare plans)
    Cons
    •Must be taken with food
    •Dose can't be adjusted, so it's not recommended for people with kidney or liver problems
    •Can cause kidney and bone problems
    •Interacts with a lot of medications
    •Not a good option for people who are pregnant, or plan to become pregnant

  • Common Side Effects of Prezista vs. Stribild

    Common Side Effects for
    •Diarrhea (9-14%)
    •Rash (6-7%)
    •Nausea (4-7%)
    •Headache (3-7%)
    •Stomach pain (6%)
    •Vomiting (2-5%)

    Side effects above were reported in adults taking this medication with ritonavir (Norvir). Side effects might differ in children.

    Common Side Effects for
    •Nausea (16%)
    •Diarrhea (12%)
    •Abnormal, strange dreams (9%)
    •Headache (7%)

  • Warnings of Prezista vs. Stribild

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes in body fat
    •Overactive immune system
    •Bleeding
    •Interactions with other medications
    Common Side Effects for
    •WORSENING OF HEPATITIS B
    •CHANGES IN KIDNEY FUNCTION
    •LIVER PROBLEMS
    •DRUG INTERACTIONS
    •BONE PROBLEMS
    •IMMUNE RECONSTITUTION SYNDROME

  • Prices with our coupons for Prezista vs. Stribild

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