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Compare Prezcobix vs. Genvoya

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezcobix (darunavir/cobicistat) and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) are both antiretroviral medications used to treat HIV infections, but they have some key differences. Prezcobix combines a protease inhibitor (darunavir) and a booster (cobicistat), while Genvoya includes an integrase strand transfer inhibitor (elvitegravir), two nucleoside reverse transcriptase inhibitors (emtricitabine and tenofovir alafenamide), and a booster (cobicistat). Prezcobix is typically taken with other HIV medications, whereas Genvoya is a complete regimen on its own. Both medications are available only as a brand-name medication. Both medications need to be taken with food and are taken once daily. However, Genvoya has the risk of worsening hepatitis B if the medication is stopped suddenly. Prezcobix, on the other hand, has specific interactions with other medications and must be used carefully in people with sulfa allergies.

  • Prezcobix (darunavir / cobicistat)
    Genvoya
  • Prezcobix (darunavir / cobicistat)
    Genvoya

  • Summary of Prezcobix vs. Genvoya

    Summary for HIV ARV
    Prescription only

    Prezcobix (darunavir / cobicistat), also known as DRV/COBI, is an antiretroviral (ARV) medication that treats HIV (human immunodeficiency virus) infections in people who weigh at least 88 pounds. It's typically taken with other HIV ARVs to make up a complete treatment regimen. Prezcobix (darunavir / cobicistat) is an oral tablet that's taken once daily. It's important to take the medication every day to prevent HIV drug resistance (when HIV medications no longer work). A side effect of Prezcobix (darunavir / cobicistat) is a skin rash that appears within the first month of treatment, but it typically goes away on its own.

    Summary for HIV ARV combo
    Prescription only

    Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide) is a combination antiretroviral therapy (ART) that treats human immunodeficiency virus (HIV) infections in adults and children. It's made up of two nucleoside reverse transcriptase inhibitors (NRTIs), emtricitabine and tenofovir alafenamide; an integrase strand transfer inhibitor (INSTI) called elvitegravir; and a "booster" medication known as cobicistat. Genvoya is taken by mouth, typically once daily. Some common side effects of this medication include nausea and diarrhea. It's not available as a generic medication.

  • Indications of Prezcobix vs. Genvoya

    Indications for
    •Treatment of HIV infection in adults and children weighing at least 88 pounds
    Indications for
    •Treatment of HIV infection

  • Pros and Cons of Prezcobix vs. Genvoya

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Combines two medications into one pill for convenience
    •Safe to use in adults and children weighing at least 88 pounds
    Cons
    •Interacts with many medications, such as certain statins and blood thinners
    •Must be used carefully in people with sulfa allergies
    •Not recommended during pregnancy (being pregnant can cause the medication to work less well)
    Pros and Const for HIV ARV combo
    Pros
    •Is a complete regimen for HIV treatment
    •Only taken once a day
    •Taken by mouth
    Cons
    •Needs to be taken with food
    •Can’t take while pregnant
    •Can worsen hepatitis B if you stop taking the medication all of a sudden

  • Common Side Effects of Prezcobix vs. Genvoya

    Common Side Effects for

    Side effects below were reported in at least 5% of adults taking Prezista (darunavir) with ritonavir (Norvir) during clinical studies.

    •Diarrhea
    •Nausea
    •Stomach pain
    •Vomiting
    •Headache
    •Rash

    Side effects below were reported in at least 5% of adults taking Tybost (cobicistat) with other HIV medications in clinical studies.

    •Jaundice
    •Rash
    Common Side Effects for
    •Nausea (11%)
    •Diarrhea (7%)
    •Headache (6%)
    •Feeling tired (5%)

  • Warnings of Prezcobix vs. Genvoya

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes to blood test results for kidney function
    •Kidney problems when used with tenofovir disoproxil fumarate (TDF)
    •High blood sugar
    •Changes in body fat
    •Overactive immune system
    •Risk of bleeding in people with hemophilia
    •Interactions with other medications
    Common Side Effects for
    •Worsening of hepatitis B infection
    •Kidney problems
    •Liver problems and lactic acidosis
    •Overactive immune system
    •Interaction with other medications

  • Prices with our coupons for Prezcobix vs. Genvoya

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