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Compare Evotaz vs. Prezcobix

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Evotaz (atazanavir/cobicistat) and Prezcobix (darunavir/cobicistat) are both antiretroviral medications used to treat HIV, but they have some differences. Evotaz is approved for people who weigh at least 77 pounds, while Prezcobix is for those who weigh at least 88 pounds. Both medications combine a protease inhibitor with a booster, but Evotaz uses atazanavir as the protease inhibitor, whereas Prezcobix uses darunavir. You need to take both medications once a day with food. Both medications can cause jaundice and are not recommended during pregnancy. Prezcobix can cause severe skin reactions and must be used carefully if you have a sulfa allergy. Both medications interact with many other medications, so it's important to tell your healthcare provider about all the medications you are taking.

  • Evotaz (atazanavir / cobicistat)
    Prezcobix (darunavir / cobicistat)
  • Evotaz (atazanavir / cobicistat)
    Prezcobix (darunavir / cobicistat)

  • Summary of Evotaz vs. Prezcobix

    Summary for Antiretroviral
    Prescription only

    Evotaz (atazanavir / cobicistat) is a combination medication that's taken as part of an antiretroviral (ARV) regimen to treat HIV (human immunodeficiency virus). It's approved for people with HIV who weigh at least 77 pounds. Evotaz (atazanavir / cobicistat) is a tablet that's taken once a day with food. It must be taken along with other HIV ARV medications. Evotaz (atazanavir / cobicistat) can cause side effects, including rash and jaundice (yellowing of the skin or eyes).

    Summary for HIV ARV
    Prescription only

    Prezcobix (darunavir / cobicistat), also known as DRV/COBI, is an antiretroviral (ARV) medication that treats HIV (human immunodeficiency virus) infections in people who weigh at least 88 pounds. It's typically taken with other HIV ARVs to make up a complete treatment regimen. Prezcobix (darunavir / cobicistat) is an oral tablet that's taken once daily. It's important to take the medication every day to prevent HIV drug resistance (when HIV medications no longer work). A side effect of Prezcobix (darunavir / cobicistat) is a skin rash that appears within the first month of treatment, but it typically goes away on its own.

  • Indications of Evotaz vs. Prezcobix

    Indications for
    •Treatment of HIV
    Indications for
    •Treatment of HIV infection in adults and children weighing at least 88 pounds

  • Pros and Cons of Evotaz vs. Prezcobix

    Pros and Const for Antiretroviral
    Pros
    •Taken once a day
    •Combination tablet, so there are fewer pills to take
    •Same dose for adults and children who weigh at least 77 pounds
    •Can take if you have a sulfa allergy
    Cons
    •Need to take with food
    •Might cause jaundice (yellowing of skin or eyes)
    •Interacts with a lot of medications, such as certain other HIV medications, statins, and certain blood thinners
    •Must be separated from medications that treat heartburn and indigestion by a certain amount of time
    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Combines two medications into one pill for convenience
    •Safe to use in adults and children weighing at least 88 pounds
    Cons
    •Interacts with many medications, such as certain statins and blood thinners
    •Must be used carefully in people with sulfa allergies
    •Not recommended during pregnancy (being pregnant can cause the medication to work less well)

  • Common Side Effects of Evotaz vs. Prezcobix

    Common Side Effects for
    •Jaundice (yellowing of the skin or eyes; up to 6%)
    •Rash (5%)
    Common Side Effects for

    Side effects below were reported in at least 5% of adults taking Prezista (darunavir) with ritonavir (Norvir) during clinical studies.

    •Diarrhea
    •Nausea
    •Stomach pain
    •Vomiting
    •Headache
    •Rash

    Side effects below were reported in at least 5% of adults taking Tybost (cobicistat) with other HIV medications in clinical studies.

    •Jaundice
    •Rash

  • Warnings of Evotaz vs. Prezcobix

    Common Side Effects for
    •Heart rhythm problems
    •Rash and other severe skin reactions
    •Kidney problems
    •Kidney stones or gallstones
    •Liver problems
    •High bilirubin levels
    •Interactions with other medications (including certain HIV ARVs)
    •Overactive immune system
    •High blood sugar
    •Changes in body fat
    •Risk of bleeding in people with hemophilia
    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes to blood test results for kidney function
    •Kidney problems when used with tenofovir disoproxil fumarate (TDF)
    •High blood sugar
    •Changes in body fat
    •Overactive immune system
    •Risk of bleeding in people with hemophilia
    •Interactions with other medications

  • Prices with our coupons for Evotaz vs. Prezcobix

    Learn more about Evotaz
    Learn more about Prezcobix

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