Head-to-head comparisons of medication uses, side effects, warnings, and more.
Prezista (darunavir)
Fosamprenavir (Lexiva)
Prezista (darunavir)
Fosamprenavir (Lexiva)
Summary of Prezista vs. Lexiva
Summary for HIV ARV
Prescription only
Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.
Summary for HIV ARV
Prescription only
Fosamprenavir (Lexiva) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's typically taken twice daily, usually in combination with a "booster," like ritonavir (Norvir), to help fosamprenavir (Lexiva) work better against the virus. Fosamprenavir (Lexiva) isn't a first-choice option for HIV anymore because it can cause serious side effects (e.g., rash, diarrhea, and nausea) and can interact with many other medications.
Indications of Prezista vs. Lexiva
Indications for
•Treatment of HIV infection in people aged 3 years and older
Indications for
•Treatment of HIV infection
Pros and Cons of Prezista vs. Lexiva
Pros and Const for HIV ARV
Pros
•Taken once a day by mouth
•Available as an oral suspension, so it's convenient if you have trouble swallowing pills
•Safe to take during pregnancy
Cons
•Requires regular blood work and lab tests
•Interacts with many medications
•Must be used carefully in people with sulfa allergies
Pros and Const for HIV ARV
Pros
•Available in a liquid form for people who have difficulty swallowing pills
•Can be used in children age 4 weeks and older
•Tablets can be taken with or without food
Cons
•Interacts with many medications
•Requires regular blood work and lab tests to make sure your liver is healthy
•Likely to cause high blood sugar and cholesterol levels
Common Side Effects of Prezista vs. Lexiva
Common Side Effects for
•Diarrhea (9-14%)
•Rash (6-7%)
•Nausea (4-7%)
•Headache (3-7%)
•Stomach pain (6%)
•Vomiting (2-5%)
Side effects above were reported in adults taking this medication with ritonavir (Norvir). Side effects might differ in children.
Common Side Effects for
•Diarrhea (5-13%)
•Higher levels of fats in the body (up to 11%)
•Higher liver labs (6-8%)
•Rash (3-8%)
•Nausea (3-7%)
Please note: The side effects above include those reported by people who also took ritonavir (Norvir) with fosamprenavir (Lexiva) during clinical trials.