Compare Prezista vs. Lexiva

Darunavir (Prezista) and fosamprenavir (Lexiva) are both protease inhibitors used to treat HIV infections. They work by blocking a protein called protease, which helps prevent the virus from making copies of itself. Both medications are taken orally and are usually taken with a booster, like ritonavir (Norvir), to enhance their effectiveness. However, there are several differences between them. Darunavir is typically taken once a day, while fosamprenavir (Lexiva) is usually taken twice daily. Darunavir is available as a tablet or oral suspension and is considered safe during pregnancy, whereas fosamprenavir is not a first-choice option for pregnant individuals. Common side effects of darunavir include diarrhea, rash, and nausea, while fosamprenavir can cause diarrhea, higher levels of fats in the body, and rash. Both medications can interact with many other drugs, so be sure your prescriber and pharmacist have a complete list of your medications. Both medications contain a sulfa component, so talk to your prescriber if you have a sulfa allergy.