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Compare Prezista vs. Crixivan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Prezista (darunavir) and Crixivan (indinavir) are both protease inhibitors used to treat HIV, but they have some key differences. Prezista (darunavir) is still available and commonly used, while Crixivan (indinavir) has been discontinued in the U.S. due to low demand and the availability of newer treatments. Prezista (darunavir) must be taken with a booster like ritonavir (Norvir) and food to be effective, whereas Crixivan (indinavir) did not have this requirement. Prezista (darunavir) is available as both a tablet and an oral suspension, making it easier for those who have trouble swallowing pills. Additionally, Prezista (darunavir) can be used in children as young as 3 years old and is considered safe during pregnancy, while Crixivan (indinavir) had more limitations and side effects, which contributed to its decline in use. Lastly, Prezista (darunavir) requires regular blood tests to monitor liver health and interactions with other medications, highlighting the need for careful management.

  • Prezista (darunavir)
    Crixivan (indinavir)
  • Prezista (darunavir)
    Crixivan (indinavir)

  • Summary of Prezista vs. Crixivan

    Summary for HIV ARV
    Prescription only

    Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.

    Summary for HIV ARV

    Crixivan (indinavir) was one of the first HIV antiretroviral (ARV) medications approved by the FDA. Due to side effects and medication interactions, it has not been a first choice treatment option for many years and has been discontinued in the U.S.

  • Indications of Prezista vs. Crixivan

    Indications for
    •Treatment of HIV infection in people aged 3 years and older
    Indications for

  • Pros and Cons of Prezista vs. Crixivan

    Pros and Const for HIV ARV
    Pros
    •Taken once a day by mouth
    •Available as an oral suspension, so it's convenient if you have trouble swallowing pills
    •Safe to take during pregnancy
    Cons
    •Requires regular blood work and lab tests
    •Interacts with many medications
    •Must be used carefully in people with sulfa allergies
    Pros and Const for HIV ARV
    Pros
    Cons

  • Common Side Effects of Prezista vs. Crixivan

    Common Side Effects for
    •Diarrhea (9-14%)
    •Rash (6-7%)
    •Nausea (4-7%)
    •Headache (3-7%)
    •Stomach pain (6%)
    •Vomiting (2-5%)

    Side effects above were reported in adults taking this medication with ritonavir (Norvir). Side effects might differ in children.

    Common Side Effects for

  • Warnings of Prezista vs. Crixivan

    Common Side Effects for
    •Liver problems
    •Severe skin and allergic reactions
    •Changes in body fat
    •Overactive immune system
    •Bleeding
    •Interactions with other medications
    Common Side Effects for

  • Prices with our coupons for Prezista vs. Crixivan

    Learn more about Prezista
    Learn more about Crixivan

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