Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Prezista (darunavir) and Viracept (nelfinavir) are both protease inhibitors used to treat HIV, but they have some key differences. Prezista (darunavir) is typically taken once a day with a booster like ritonavir (Norvir) and food, while Viracept (nelfinavir) is taken two to three times a day with meals. Prezista (darunavir) is available as an oral tablet or suspension, making it easier for those who have trouble swallowing pills, whereas Viracept (nelfinavir) offers tablets that can be dissolved in water and an oral powder. Prezista (darunavir) is safe to take during pregnancy, but Viracept (nelfinavir) has limited reports suggesting potential risks for birth defects and liver problems. Additionally, Prezista (darunavir) must be used cautiously in people with sulfa allergies, while Viracept (nelfinavir) should be avoided in those with moderate or severe liver problems. Both medications interact with many other medications, but Viracept (nelfinavir) has a higher frequency of causing diarrhea, especially in children.
Prezista (darunavir)
Viracept (nelfinavir)
Prezista (darunavir)
Viracept (nelfinavir)
Summary of Prezista vs. Viracept
Summary for HIV ARV
Prescription only
Prezista (darunavir) is an oral tablet or suspension that's used as part of an antiretroviral (ARV) regimen to treat human immunodeficiency virus (HIV) infections. It's often taken in combination with a "booster," like ritonavir (Norvir), to help Prezista (darunavir) work better against the virus. Rarely, this medication can cause a skin rash within the first month of treatment, but it typically goes away on its own. Lastly, let your provider know if you have a history of sulfa allergy since Prezista (darunavir) contains a "sulfa" component.
Summary for HIV ARV
Prescription only
Viracept (nelfinavir) is a protease inhibitor (PI) used to treat human immunodeficiency virus (HIV) in people ages 2 years and older. It works by preventing the HIV virus from making copies of itself and spreading. You take Viracept (nelfinavir) by mouth, typically twice or three times a day with a meal. One of the most common side effects Viracept (nelfinavir) can cause is diarrhea. Your provider might recommend over-the-counter medications, like loperamide (Imodium A-D), to help ease your symptoms.
Indications of Prezista vs. Viracept
Indications for
•Treatment of HIV infection in people aged 3 years and older