Key takeaways
Prezista (darunavir) and Invirase (saquinavir) are both protease inhibitors used to treat HIV infections that must be taken with a booster, ritonavir (Norvir). However, there are several differences between them. Prezista is approved for use in people aged 3 years and older, while Invirase has been discontued and is no longer available in the U.S. Prezista is available as an oral tablet or suspension and is typically taken once a day. Invirase was available only as a tablet taken twice a day. Prezista can be used during pregnancy. Common side effects of Prezista include diarrhea, rash, and nausea.
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