Key takeaways
Prezcobix (darunavir/cobicistat) and Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir) are both antiretroviral (ARV) medications used to treat HIV infections. They both contain cobicistat, a booster medication. However, they have some important differences. Prezcobix combines a protease inhibitor (darunavir) with cobicistat and is typically used with other HIV medications, while Stribild is a complete single-tablet regimen that includes an integrase inhibitor (elvitegravir) and two nucleoside reverse transcriptase inhibitors (emtricitabine and tenofovir). Both medications are taken once daily with food and are not recommended during pregnancy. Common side effects of Prezcobix include diarrhea, nausea, and rash, whereas Stribild may cause nausea, diarrhea, and abnormal dreams. Both medications interact with many other drugs, so it's important to discuss all medications you're taking with your prescriber and pharmacist. Prezcobix contains a sulfa component, so talk to your prescriber if you have a sulfa allergy.
